咸宁地区胃疾病患者幽门螺杆菌感染及耐药性分析

Analysis on infection and drug resistance of Helicobacter pylori in patients with gastric diseases in Xianning area

目的:探讨咸宁地区胃疾病患者幽门螺杆菌(Helicobacter pylori,Hp)感染及耐药状况。方法:从402例胃疾病患者的胃黏膜活检组织中共分离、鉴定出267株Hp。用Kirby-Baner药敏纸片法检测,Hp对甲硝唑、克拉霉素、阿莫西林、左氧氟沙星、庆大霉素的耐药率。结果:咸宁地区胃疾病患者Hp感染率为66.4%,不同胃疾病、区域之间感染率差异有统计学意义(P<0.05),不同性别之间感染率差异无统计学意义(P>0.05),Hp对甲硝唑、克拉霉素、阿莫西林、左氧氟沙星、庆大霉素的耐药率分别为71.5%、11.0%、12.2%、6.2%、2.2%。结论:咸宁地区胃疾病患者Hp感染率较高,其感染率农村高于城市,Hp感染是胃疾病的发生因素。Hp对甲硝唑的耐药性严重,克拉霉素和阿莫西林为本地区根除Hp感染的首选抗菌药物。

Objective：To investigate the status of Helicobacter pylori（Hp） infection and drug resistance in gastric disease patients from Xianning area.Methods：267 Hp isolates were collected and identified from the gastric mucosa of 402 patients with peptic ulcer and gastritis.Kirby–Baner method was used as antimicrobial susceptibility test for assaying the drug resistance rate of Hp to metronidazole,clarithromycin,amoxicillin,levofloxacin and gentamycin.Results：In Xianning area,the infection rate of Hp in 402 patients with gastric disease was 66.4%,there was statistic significance between different regions and gastric diseases（P0.05）.The drug resistance rates of Hp isolates to metronidazole,clarithromycin,amoxicillin,levofloxacin and gentamycin were 71.5%,11.0%,12.2%,6.2% and 2.2%.Conclusion：The higher Hp infection rates were showed in Xianning area.Hp infection rates in rural areas were higher than those in urban areas.Hp infection is correlated with he occurrence of gastric diseases.The drug resistance of Hp isolates to metronidazole is serious.Clarithromycin and amoxicillin are the first choice drug in treating Hp infection in the native area.