结肠癌患者术中植入缓释型氟尿嘧啶的临床评估

Clinical evaluation of implanting sustained-release fluorouracil during colon carcinoma operation

目的：评估结肠癌患者术中植入缓释型氟尿嘧啶的临床意义。方法：回顾性分析我院2009年1月~2010年12月50例DukesB、C期结肠癌患者,经根治性切除加植入缓释型氟尿嘧啶组（A组,n=25）和单纯根治性切除术组（B组,n=25）,对比两组手术前后1周CEA、CA199及CA242浓度变化情况。结果：A、B组患者手术后1周外周血CEA、CA199及CA242浓度较手术前1周均显著降低,差异有统计学意义（P〈0.05）,A组较B组降低更明显,差异有统计学意义（P〈0.05）。结论：结肠癌患者术中植入缓释型氟尿嘧啶能显著降低外周血CEA、CA199及CA242浓度,一定程度抑制远处转移,该治疗方式值得临床推广。

Objective：To investigate the clinical significance of implanting sustained-release fluorouracil in surgical treatment of colon carcinoma.Methods：The data of 50 patients with colon carcinoma（Dukes classification B and C） undergone surgical treatment from January 2009 to December 2010 were retrospectively analyzed.25 cases underwent radical excision and implantation of sustained-release fluorouracil（group A） and other 25 cases underwent simple radical excision（group B）.The concentrations of CEA,CA199 and CA242 at one week before and after operation were compared between the two groups.Results：The levels of CEA,CA199 and CA242 at 1 week after operation were significantly lower than those at 1 week before operation with statistical difference（P0.05）.The decrease of group A was more obvious than group B,which showing statistical difference（P0.05）.Conclusion：Implanting sustained-release fluorouracil during operation in colon carcinoma could obviously reduce the concentrations of CEA,CA199 and CA242 in peripheral blood and restrain distant metastasis,which is worth being promoted in clinic.