孟鲁司特钠对慢性阻塞性肺病急性加重期的疗效观察

Effective observation of montelukast sodium in treatment of acute exacerbation chronic obstructive pulmonary disease

目的:观察孟鲁斯特钠在慢性阻塞性肺疾病(chronic obstrultive pulmonay disease,COPD)中的治疗效果。方法:将48例COPD急性加重期患者随机分为两组,对照组给予吸氧、抗生素、止咳、化痰等常规治疗,并吸入舒利迭,治疗组在此基础上加用孟鲁司特钠口服治疗,14天后测量肺功能及6分钟步行距离。结果:经治疗14天后患者肺功能FEV1(L),FEV1%Pred及6分钟步行距离较前改善,治疗组与对照组比较差异具有统计学意义。治疗组患者未见明显不良反应。结论:孟鲁司特钠在COPD的治疗中是一种安全有效的药物。

Objective：To observe the effect of montelukast sodium in treatment of acute exacerbation chronic obstructive pulmonary disease（AECOPD）.Methods：48 patients with AECOPD in our department were divided into two groups randomly.All patients were routinely treated by oxygen inhalation,antibiotics,cough relieving and eliminating sputum and also seretide was inhaled.On the basis of routine therapy,the treatment group was added oral montelukast sodium.After 14 d treatment,the lung function and maxium walking distance in 6 min（MWD6MT） were determined.Results：After 14 d treatment,FEV1（L）,FEV1% Pred and MWD6MT all were improved,but the difference between the treatment group and the control group showed statistical significance.There was no adverse reactions founded in the treatment group.Conclusion：Montelukast sodium is a safe and effective drug in treatment of AECOPD.