NF-κB在急性脊髓损伤中的研究现状及前景

Advances and prospects on studies of NF-κB in acute spinal cord injury

核转录因子-κB是一种重要的转录因子,在急性脊髓损伤(Acute spinal cord injury,ASCI)后早期即可高表达,在ASCI后所出现的炎性反应、免疫应答、局部缺血再灌注、游离钙释放、过氧化基团异常变化及细胞凋亡等起着重要作用。同时,NF-κB又具有神经保护作用。因此,如何有效抑制NF-κB的损伤作用,充分发挥其保护作用,在治疗ASCI中具有重要意义。

NF-κB is a considerable transcription factor,highly expressed in the early stage of acute spinal cord injury.It plays an important role in the inflammatory response,immune response,local ischemia reperfusion,release of free calcium,abnormal changes of peroxide-based groups and apoptosis.However,NF-κB is essential for neuroprotective effects as wel1.Hence it is of great significant to effectively inhibit the damage effect of NF-κB and bring its protective effect into full play in the treatment of acute spinal cord injury.