冠心病患者尿微量蛋白与血管内皮因子相关性研究

Correlation between microalbuminuria and vascular endothelial growth factor in coronary heart disease

目的探讨尿微量蛋白（mALB）与血管内皮因子（VEGF）相关性在冠心病（CHD）患者中的临床意义。方法选择64例CHD患者为观察组，30名健康成人为对照组。其中观察组分为急性冠脉综合征（ACS）组和稳定型心绞痛（SA）组，ACS组包括不稳定型心绞痛（UAP）和急性心肌梗死（AMI）患者。分别测定mALB、VEGF、血糖、血脂、心肌酶，比较分析各组间mALB与VEGF、肌酸激酶及其同工酶（CK—MB）的相关性。结果ACS患者mALB、VEGF水平明显高于sA患者及对照组（P均〈0．01），CHD组mALB、VEGF水平分别与CK—MB、血肌钙蛋白I（cTnI）呈显著正相关（r分别为0．61、0．56、0．63、0．64，P均〈0．05或0．01）。结论检测mALB、VEGF水平对判断冠状动脉粥样硬化斑块的稳定性及冠心病的病情程度有一定的临床价值。

Objective To outline the clinical significances of correlation-ship between microlalbuminuria （mALB） and vascular endothelial growth factor （VEGF） in coronary heart disease（CHD）. Methods 64 patients with CHD were selected in observation group and 40 healthy subjects were chosen in control group, patients in ob- servation group were divided into acute coronary syndrome（ACS） group and stable angina pectoris（SA） group. ACS group were further subdivided into unstable angina pectoris （UAP） group and acute myocardial infarction （AMI） group. In each group, the levels of fasting blood lipid, blood sugar, CK-MB, mALB and VEGF were measured and the separate correlation between mALB or VEGF and cTnI or CK-MB was comparatively analyzed. Results In patients with CHD, there was a significant correlation between mALB and VEGF （r=0.6917, P〈0.01 ）. Both UREA and VEGF were higher in ACS group, compared to SA group and normal subjects （all P〈0.01 ）. MALB or VEGF in CHD group were positively associated with CK-MB, cTnI respectively （r=0.6358,0.6414, r=0.6535, 0.6125, respectively, P〈0.05 or P〈0.01 ）. Conclusion mALB and VEGF are the good parameters in identifying the stability of coronary atherosclerosis plaques and assessing the level of cardiovascular risk in CHD patients.