摘要
目的制备复方头孢羟氨苄分散片。方法以均匀分散时间为指标,采用正交设计试验优选复方头孢羟氨苄分散片处方工艺。结果优选的处方为:以改良淀粉为填充剂,交联聚乙烯吡咯烷酮(PVPP)为崩解剂,崩解剂的质量分数为12%。优化工艺条件下制备的头孢羟氨苄分散片的均匀分散时间为30 s,45 min的溶出度大于99%。结论所优选的处方合理,工艺简单,符合分散片质量标准要求。
Objective To optimize the formulation of compound cefadroxil dispersible tablet.Methods Orthogonal L9(34) test was designed to screen out the best prescription with dispersing homogeneity as index.Results The optimized prescription was as follows:filled with modified starch,disintegrated with polyvinylpyrrolidone(PVPP) and its amount was 12%.The average dispersing time was 30 s and its dissolution rate within 45 min was more than 99%.Conclusion The optimal prescription is feasible and easy,conforming to the requirements of dispersible tablets.
出处
《广东药学院学报》
CAS
2011年第3期227-229,共3页
Academic Journal of Guangdong College of Pharmacy
基金
广州市科技计划项目(2007Z2-E5021)