CT引导下经皮射频消融治疗卵巢癌肝脏转移肿瘤的初步疗效

The clinical application of CT-guilded percutaneous radiofrequency ablation in the treatment of liver metastasis caused by ovarian ancer

目的探讨CT引导下经皮射频消融治疗(RFA)治疗卵巢癌肝脏转移瘤的近期疗效、安全性和不良反应。方法 2006年1月至2010年7月,本院8例卵巢癌肝转移的患者在CT引导下进行RFA治疗,病灶总数12处,平均直径为3.0cm(1.5～4.5cm)。RFA治疗前2周内和治疗后1月常规进行CA125、肝功能、CT双期增强检查,了解局部治疗效果、安全性和不良反应。结果 所有病人均平稳安全完成治疗,11处病灶术后复查增强CT肿瘤完全坏死,有1例患者1处病灶在射频消融治疗后肝脏病灶边缘残留。所有患者CA125出现了不同程度的下降,术中及术后没有出现严重的并发症。结论 CT引导下RFA治疗卵巢癌肝脏转移瘤是一种安全、有效、并发症少的微创治疗方法。通过RFA治疗,卵巢癌肝脏转移患者可以实现理想的肿瘤细胞减灭治疗。

Objective To analyze the local therapeutic efficacy,side effect,safety,and complication of 8 patients with liver metastasis caused by ovarian cancer treated by CT-guilded percutaneous radiofrequency ablation（RFA）.Methods CT-guided RFA was performed in 8 patients with liver metastasis caused by ovarian cancer,the sum total of the lesions was 12.The diameter of the lesions ranged from 1.5 cm to 4.5 cm,with a mean diameter of 3.0 cm.The clinical value was evaluated through CA125 and enhanced CT scanning before and after therapy.Results： Of 12 lesions,complete ablation of the tumor revealed on the follow-up enhanced CT scans after RFA was obtained in 11 lesions.Residual tumor enhancement was demostrated in the remaining 1lesion,indicating that the ablation of the tumor was incomplete.CA125 value was declined in all patients and in 3 cases it returns to normal.No serious complications occurred.Conclusion CT-guilded percutaneous radiofrequency ablation is safe,effective and reliable in the treatment of liver metastasis caused by ovarian cancer.Cytoreduction can be achieved with RFA.