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Notch3信号通路与脑血管病 被引量：3

Notch3 signaling pathway and cerebrovascular diseases
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摘要 Notch通路是进化保守的信号转导通路，由复杂的相互作用的系统构成，其功能与胚胎发育和细胞分化调节有关。近年来研究表明，Notch通路与特定的人类疾病有关。其中，Notch3信号通路与神经系统发育和血管结构完整性关系密切。Notch3点突变可引起伴皮质下梗死和白质脑病的常染色体显性遗传性脑动脉病。 The Notch pathway is an evolutionarily conserved signal transduction pathway. It consists of a complex system of interaction. Its function is associated with the embryonic development and cell differentiation regulation. Studies in recent years have demonstrated that Notch pathway is associated with specific human diseases, in which Notch3 signaling pathway is closely associated with the nervous system development and the structural integrity of blood vessels. Notch3 mutation may cause cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.
作者 李莹 张微微 李静
机构地区 北京军区总医院神经内科
出处 《国际脑血管病杂志》 北大核心 2011年第6期461-465,共5页 International Journal of Cerebrovascular Diseases
关键词 NOTCH3蛋白 人 受体 Notch 信号转导 脑缺血 脑血管障碍 CADASIL NOTCH3 protein, human Receptors, Notch Sisal transduction Brainischernia Cerebrovascular disorders CADASIL
分类号 R74 [医药卫生—神经病学与精神病学]
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参考文献33

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同被引文献65

  • 1曹美嫦,文林兰,吴丹.氧疗、白炽灯照射治疗褥疮的疗效观察[J].当代护士（中旬刊）,2005,12(2):57-58. 被引量：4
  • 2王筠,张军平.从中医络病学说认识血管新生[J].中国中医基础医学杂志,2005,11(7):493-494. 被引量：21
  • 3王淑美,徐晓玉,张文亮,胡益勇,陈伟海.桃红四物汤及其拆方对血管生成的影响[J].中药药理与临床,2005,21(4):4-7. 被引量：29
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  • 5Lee JS, Choi JC, Kang SY, et al. Effects of lacunar infarctions on cognitive impairment in patients with cerebral autosomal-dominantarteriopathy with subcortical infarcts and leukoencephalopathy [ J ]. J Clin Neurol, 2011, 7:210-214.
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国际脑血管病杂志
2011年 第6期

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