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血管紧张素转化酶2-血管紧张素(1—7)-Mas轴与肾脏

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摘要 血管紧张素转化酶2-血管紧张素(1—7)-Mas轴是肾素-血管紧张素系统的一个新分支,该轴能对抗血管紧张素Ⅱ(AngII)、调节心血管和肾脏功能,发挥降低血压、保护心血管功能,Ang(1—7)在调节肾脏血管、小管转运、细胞生长、血压方面均发挥重要作用。本文就该轴的生物学特点及其对肾脏的影响作一综述。
出处 《国际泌尿系统杂志》 2011年第4期519-522,共4页 International Journal of Urology and Nephrology
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  • 1Unger T, Culman J, Gohlke P. Angiotensin II receptor blockade and end-organ protection: pharmacological rationale and evidence. J Hypertens 1998; 16 (Suppl 7): S3-9.
  • 2Zimpelmann J, Kumar D, Levine DZ, Wehbi G, Imig JD, Navar LG, et al. Early diabetes mellitus stimulates proximal tubule renin mRNA expression in the rat. Kidney Int 2000; 58: 2320- 30.
  • 3Wehbi GJ, Zimpelmann J, Carey RM, Levine DZ, Burns KD. Early streptozotocin-diabetes mellitus downregulates rat kidney AT(2) receptors. Am J Physiol Renal Fluid Electrolyte Physiol 2001; 280: F254-65.
  • 4Gilbert RE, Cox A, Wu LL, Allen T J, Hulthen L, Jerums G, et al. Expression of transforming growth factor-β1 and type Ⅳ col- lagen in the renal tubulointerstitium in experimental diabetes: effects of angiotensin converting enzyme inhibition. Diabetes 1998; 47: 414-22.
  • 5Brenner BM, Cooper ME, de Zeeuw D, Keane WF, Mitch WE, Parving HH, et al. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med 2001; 345: 861-9.
  • 6Lewis EJ, Hunsicker LG, Clarke WR, Berl T, Pohl MA, Lewis JB,et al. Renoprotective effect of the angiotensin receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. N Engl J Med 2001; 345:851-60
  • 7Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, et al. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin Ⅰ to angiotensin 1-9. Circ Res 2000; 87: E1-9.
  • 8Tipnis SR, Hooper NM, Hyde R, Karran E, Christie G, Turner AJ. A human homolog of angiotensin-converting enzyme: cloning and functional expression as a captopril-insensitive carboxypeptidase. J Biol Chem 2000; 275: 33238--43.
  • 9Vickers C, Hales P, Kaushik V, Dick L, Gavin J, Tang J, et al. Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase. J Biol Chem 2002; 277:14 838-43.
  • 10Harmer D, Gilbert M, Borman R, Clark KL. Quantitative mRNA expression profiling of ACE2, a novel homologue of angiotensin converting enzyme. FEBS Lett 2002; 532: 107-10.

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