甲状腺过氧化物酶抗体检测对慢性丙型肝炎患者的临床意义

Clinical significance of thyroid antibody detection in patients with chronic hepatitis C

目的检测慢性丙型肝炎患者甲状腺过氧化物酶抗体的临床意义。方法对健康对照组62例,慢性乙型肝炎患者组68例,慢性丙型肝炎患者组74例,分别检测甲状腺过氧化物酶抗体(TPOAB);对慢性丙型肝炎患者检测丙氨酸氨基转移酶(ALT)、抗核抗体(ANA)、抗线粒体抗体(AMA)及类风湿因子(RF)。结果慢性丙型肝炎患者组TPOAB阳性率(16.2%)明显高于健康对照组TPOAB阳性率(4.8%)和慢性乙型肝炎患者组TPOAB阳性率(7.3%);慢性丙型肝炎患者中,女性患者TPO-AB的阳性率(66.7%)明显高于男性患者TPOAB的阳性率(33.3%),TPOAB阳性慢性丙型肝炎患者的ALT(75.0%)、ANA(41.6%)、AMA(41.6%)、RF(33.3%)阳性率明显高于TPOAB阴性慢性丙型肝炎患者ALT(24.2%)、ANA(12.9%)、AMA(12.9%)、RF(9.6%)阳性率。结论 HCV感染可诱导甲状腺的自身免疫反应,使患者血清中出现甲状腺过氧化物酶抗体,这对丙型肝炎患者的诊断和治疗有一定的参考价值。

Objective To study the clinical significance of Thyroid Peroxidase Antibody in HCV patients. Methods The serum thyroid peroxidase eroxidase antibody（TPOAB） were detected by immunofluorescence assay in 62 healthy subjects,68 patients with chronic hepatitis B,74 patients with chronic hepatitis C,the serum ALT,ANA,AMA,RF in patients with chronic hepatitis C were determined. Results The positive rate（16.2%） of TPOAB in 74 patients with chronic hepatitis C was significantly higher than that in patients with chronic hepatitis 13 and healthy subjects,the positive rate（66.7%） of TPOAB in patients with chronic hepatitis C type of female patients was significantly higher than that（33.3 % ） in the male patients,in TPOAB（＋） chronic hepatitis C patients and TPOAB（-） chronic hepatitis C patients,The positive rate of ALT were 75.0% and 24.2% ,ANA were 41.6% and 12.9%, AMA were 41.6% and 12.9%, RF were 33.3% and 9.6% respectively. Conclusion HCV infection can induce thyroid autoimmune reactions resulting in production of thyroid peroxidase antibody and its titer is important indicates helpful for the diagnosis and treatment of HCV patients.