正常和子宫内膜异位症在位内膜的对比研究

Comparative ultrastructural study on eutopic endometrium of endometriotic and normal reproductive-aged women

目的对正常和子宫内膜异位症在位内膜的超微结构进行对比研究,探讨子宫内膜异位症的发病机制。方法对子宫内膜异位症在位内膜6例以及正常育龄妇女的子宫内膜3例进行超微结构对比研究。结果子宫内膜异位症在位内膜与正常子宫内膜的超微结构存在差异,具体表现在:前者分泌细胞的微绒毛和纤毛细胞的纤毛异常增多、变长;上皮细胞胞浆内线粒体明显增多;粗面内质网明显增多、扩张;脂滴及电子致密颗粒常见;基底膜弯曲。结论子宫内膜异位症的在位内膜与正常内膜有异,其随经血倒流入腹腔后,更易于在异位种植生长。

Objective To compare the different ultrastructural characteristics of eutopic endometrium of endometriotic and normal reproductive-aged women.Methods 6 eutopic endometria of early proliferative phase from patients with endometriosis and 3 from normal reproductive-aged women were studied with transmission electron microscope.Results In comparison to normal human endometrium,the ultrastructural features of eutopic glandular epithelium of endometriosis showed differences.The microvilli covering the surface of secretory cells were longer and numerous.The cilia of ciliated cells were increased and elongated remarkably.In the cytoplasm of the epithelial cell,the number of mitochondria and rough endoplasmic reticulum（RER） were increased obviously and RER cisternae were dilated.Diffusely distributed electron-densed granules and lipid droplets were prominent.The basement membrane became markedly tortuous.Conclusion The eutopic endometrium from women with endometriosis is abnormal which may be the origin of endometriosis.