急诊介入治疗对急性心肌梗死患者多项血清因子的影响

Effect of percutaneous coronary intervention on multiple serum factors in the patients with acute myocardial infarction

目的探讨研究急性介入治疗对急性心肌梗死(Acute myocardial infarction,AMI)患者多项血清因子的影响。方法对本院2008年1月～2010年8月间收治的ST段抬高心肌梗死患者(ST elevation myocardial infarction,STEMI)42例的临床经皮冠状动脉内介入术(Percutaneous coronary intervention,PCI)治疗及指标监测信息进行回顾性研究。结果对患者在PCI治疗前后的血管内皮生长因子(Vascular endothelial growth factor,VEGF)、血清肿瘤坏死因子-α(Fumor necrosis factor-α,TNF-α)、白细胞介素-6(Interleukin-6,IL-6)、超敏C-反应蛋白(High sensitivity C-reactive protein,hs-CRP)、纤维蛋白原(Fibrinogen,Fg)进行检测,与治疗前相比这些指标差异均有统计学意义。结论多种生物活性的血清因子如TNF-α、IL-6、hs-CRP、Fg等对于急性心肌梗死疾病的发生发展及病情程度都存在着直接联系。对急性心肌梗死患者PCI手术前后的血清因子进行对比研究,有助为临床预防冠脉再狭窄提供指导。

Objective To observe the effect of PCI on multiple serum factors in the patients with acute myocardial infarction（AMI）.Methods 42 cases with ST elevation myocardial infarction（STEMI） had been chosen and made percutaneous coronary intervention（PCI）.The data of their clinical monitoring information had been investigated.Results Compared with those before treatment,indexes of VEGF,TNF-α,IL-6,hs-CRP,Fg had significant difference（P0.05）.Conclusion Indexes of VEGF,TNF-α,IL-6,hs-CRP,Fg have direct connection with AMI.To compare the serum factors before and after treatment,will be helpful to detect the prevention of coronary re-narrow.