高龄缺血性脑白质疏松症的危险因素分析

Risk factor analysis of elderly patients with ischemic leukoaraiosis

目的研究高龄缺血性脑白质疏松症(LA)发病的危险因素。方法选择均经MR I证实的高龄(均≥80岁)LA患者99例,入组后行影像学分级,分为轻度脑白质损害组、中度脑白质损害组、重度脑白质损害组;对危险因素进行单因素和多因素分析;同时测定其空腹血浆同型半胱氨酸(Hcy)水平,进行组间比较。结果在高龄患者中,血压和Hcy与LA有相关性;血浆H cy水平与缺血性LA损害程度有关,组间比较差异显著(P<0.05)。结论高龄患者中,高血压和血Hcy水平升高是缺血性LA独立危险因素。

Objective To investigate the risk factors of ischemic leukoaraiosis（LA）in elderly patients.Methods Ischemic LA group with 99 cases were studied.The 99 cases were diagnosed by MRI.classified by imaging method and divided into groups with mild,moderate and severe damage.A single-factor and multi-Logistic regression analysis was employed to determine the risk factors.The level of plasma Hcy of the patients with ischemic LA was measured.Results Hypertension and plasma Hcy were correlated in patients with LA.The plasma Hcy level of the patients with ischemic LA was significantly associated with the disease severity.The differences between the three groups were statistically significant（P〈0.05）.Conclusion Hypertension and increased plasma Hcy level are possible risk factors for ischemic LA in the eldely patients.