动脉硬化性闭塞症坏死期保守治疗适应指标观察

Observation of Indexes of Conservative Therapy of Arteriosclerosis Obliterans in Putrescence Stage

目的探讨动脉硬化性闭塞症坏死期保守治疗预后与治疗前血小板、球蛋白、C反应蛋白、凝血四项、血液流变学、踝肱指数的关系,为患者选择保守治疗提供依据。方法根据中医内、外治法及基础治疗的疗效,将150例患者分为愈显组59例、好转组71例、未愈组20例。对3组患者治疗前的血小板、球蛋白、C反应蛋白、凝血四项、血液流变学、踝肱指数检测数据进行统计学分析。结果 3组患者治疗前全血低切黏度差异有统计学意义(χ2=15.99),两两组间比较差异有统计学意义(P<0.01)。3组踝肱指数差异有统计学意义(χ2=8.56),两两组间比较差异有统计学意义(P<0.01)。3组纤维蛋白原、C反应蛋白均明显高于正常值。结论动脉硬化性闭塞症坏死期患者全血低切黏度、踝肱指数值可以作为选择保守治疗的参考指标。

Objective By investigating the relationship of platelet count,globulin,C reactive protein（CRP）,activated partial thromboplastin time,prothrombin time,thrombin time,fibrinogen,hemorheology and ankle-brachial index that before conservative therapy of arteriosclerosis obliterans in putrescence stage,to provide refenrence for conservative therapy.Methods According to the therapeutic effectiveness of internal,external Chinese medical therapy and basal therapy,150 cases were divided into recovery group with 59 cases,improving group with 71 cases and unhealing group with 20 cases,and the pre-therapy detection data of platelet count,globulin,CRP,activated partial thromboplastin time,prothrombin time,thrombin time,fibrinogen,hemorheology and ankle-brachial index of three groups were statistically analyzed.Results The low shear blood viscosity of three groups were different（χ2=15.99）,statistical significance existed between any two groups（P0.01）.The ankle-brachial index of three groups were different（χ2=8.56）,statistical significance existed between any two groups（P0.01）.The fibrinogen and CRP of the three groups were distinctly higher than normal.Conclusion The low shear blood viscosity and ankle-brachial index of arteriosclerosis obliterans in putrescence stage can be used as the reference indexes of choosing conservative therapy.