摘要
目的探讨氧化应激与血管性痴呆(VD)的关系以及针刺的抗氧化作用机制。方法通过对16例VD患者的观察,分析针刺前后简易精神状态检查(MMSE)分值和尿中氧化应激标志物8-羟基脱氧鸟苷(8-OHdG)、8-异前列腺素(8-isoPGF2α)以及硝基酪氨酸(NT)水平的变化。结果针刺后VD患者MMSE分值较针刺前明显提高,尿中8-OHdG含量明显下降,而尿中8-isoPGF2α和NT含量未见明显变化。结论针刺可降低VD患者DNA氧化损伤标志物8-OHdG的水平,发挥抗氧化作用,改善VD患者的认知功能。
Objective To investigate the correlation between oxidative stress and vascular dementia（VD）,and to explore the mechanism of the antioxidant effect of acupuncture.Methods A total of 16 VD patients were recruited.MMSE score and urinary levels of three biomarkers of oxidative stress including 8-hydroxydeoxyguanosine（8-OHdG）,8-iso-prostaglandin F2α（8-isoPGF2α） and nitrotyrosine（NT） were examined before and after acupuncture.Results Significantly higher MMSE score and lower urinary 8-OHdG level were detected in VD patients after acupuncture.However,no significant differences were found in urinary 8-isoPGF2α and NT levels between before and after acupuncture.Conclusion Acupuncture can decrease the oxidative DNA damage and increase the antioxidant defense in VD patients.
出处
《中国中医药信息杂志》
CAS
CSCD
2011年第7期18-20,共3页
Chinese Journal of Information on Traditional Chinese Medicine
基金
教育部新世纪优秀人才支持计划(NCET-09-0007)
北京市科技计划研发攻关类重大课题(D09050703550902)
天津市卫生局中医
中西医结合科研专项基金(07059)
关键词
针刺
氧化应激
标志物
血管性痴呆
简易精神状态检查
acupuncture
oxidative stress
biomarkers
vascular dementia
mini-mental state examination
