肾病综合征患者血清CA125升高的相关因素分析

目的探讨影响肾病综合征患者血清癌抗原-CAl25水平升高的相关因素。方法分别统计入选的83例肾病综合征患者的性别、年龄、体重、血白蛋白、血肌酐、24h尿蛋白定量、浆膜腔积液，采用多元线性逐步回归法、Pearson相关分析及t检验，分析肾病综合征患者血清CAl25升高的可能相关因素。结果血清CAl25水平与浆膜腔积液（计分）呈正相关（r=0．588，P〈0．01），与血白蛋白水平呈负相关（r=-0．393，P=0．006）；伴浆膜腔积液者血清CA15水平明显高于无浆膜腔积液者（P=0．012），血白蛋白〈20g／L者血清CA125水平显著高于血白蛋白≥20g／L者（P〈0．05）。结论肾病综合征患者的血清CA125水平升高，可能与浆膜腔积液及低白蛋白血症相关。

Objective To investigate the influential factors of the serum CA125 levels in patients with nephrotic syndrome. Methods Data from 83 patients with nephrotic syndrome were recorded, including gender, age, body weight, serum albumin, serum creatinine, 24h proteinuria quantification, serous cavity dropsy and so on. We adopt multiple linear stepwise regression, Pearson＇correlation analysis and t-test, respectively, to research the possible correlated factors which elevate the serum CA125 levels in patients with nephrotic syndrome. Results A positive correlation between serum CA125 levels and serous cavity dropsy （ r =0. 588, P 〈0. 001 ） , and a negative correlation （ r = - 0. 393, P = 0. 006） between serum CA125 levels and serum albumin levels were found. The serum CA125 levels in patients with serous cavity dropsy were significantly higher than those without effusion （P =0. 012）. The serum CA125 levels were significantly higher in patients with the serum albumin levels 〈 20g/L than those with the serum albumin levels ≥ 20g/L（P = 0. 04 ）. Conclusion Elevated serum CA125 levels in patients with nephrotic syndrome may closely associate with serous cavity dropsy and hypoalbuminemia.