聚硅酮在不同年龄段增生性瘢痕患者中疗效差异性分析

Curative effect difference analysis of hyperplastic scar patients with different ages treated with Silicone

目的观察不同年龄段增生性瘢痕患者在应用聚硅酮后疗效的差异并探讨其机制。方法增生性瘢痕患者30例,按年龄将患者分为两组：1~19岁组和20岁以上组,各15例。各例治疗前后取瘢痕组织对照,采用原位杂交、链酶亲合素-过氧化物酶复合物免疫化学方法（SABC）及图像分析法,观察胶原含量及转化生长因子β（TGFβ）水平的变化,并结合临床症状、物理特性、B超检查的前后数据比较。结果 1~19岁组Ⅰ？Ⅲ型胶原比例平均减少31%,TGFβ减少34%,20岁以上组Ⅰ？Ⅲ减少为37.2%,TGFβ减少39%。B超检查示：少儿组平均瘢痕厚度减少37%,成人组减少41%。结论成人组在应用聚硅酮后降低TGFβ的表达上好于少儿组,聚硅酮在不同年龄段增生性瘢痕患者疗效方面有一定差异性。

Objective To investigate the curative effect difference analysis of hyperplastic scar patients with different ages treated with Silicone.Methods 30 patients with hyperplastic scar were divided into two groups： 1-19 years old group and above 20 years old group,both groups included 15 cases.Situ hybridization,chain enzyme close grain-peroxidase complex immunochemical methods and image analysis were used in observing the collagen content,transformation growth factor beta（TGF beta） level,combined with clinical symptoms,physical characteristics,B ultrasonic examination data,to compare the difference.Results The average reduction of Ⅰ/Ⅲ collagen type in 1-19 years old group was 31%,the average reduction of TGFβ was 34%,while the percentages were 37.2% and 39% respectively in above 20 years old group,respectively.B ultrasonic examination revealed that the average reduction of scar thickness was 37% in children group,and was 41% in adult group.Conclusion Poly silicone in different age paragraph hyperplastic scar patients have certain curative differences.