超广谱β-内酰胺酶肺炎克雷伯菌耐药性分析

目的对超广谱β-内酰胺酶(ESBLs)肺炎克雷伯氏菌的耐药性研究,更好的指导临床用药。方法采用Kirby.Bauer纸片扩散法进行药敏试验检测52株产ESBLs的肺炎克雷伯菌的体外抗生素的耐药性。结果 ESBLs肺炎克雷伯菌的阳性率为21.1%,对头孢噻肟、头孢曲松、头孢唑啉耐药率达95%,所有受试菌对亚胺培南均敏感。结论产ESBLs的肺炎克雷伯菌引起的感染,治疗应首选亚胺培南、头孢西丁,其次为β-内酰胺酶抑制剂复合制剂。

Objective To investigate the antibiotic resistance rate ESBLs in producing strains Klebsiella pneumoniae.Method 52 ESBLs producing in strains Klebsiella pneumoniae were determined by the confinmmion method and antibiotic susceptibility test was assayed by Kirby-Bauer test.Results The prcvalence of ESBLs in K.pneumoniae was 2 1.1%.the resistance rate of ESBLs producing^rmns to cefotaxime,ceftriaxone and cefazolin was 95%,All tested strains were Susceptible to imipenem.Conclusions To deal with the ESBLs producing strains,imipenem,cefoxitin β-lactama/β-lactmase inhibitor combinations can be used.