乙型肝炎病毒感染对慢性乙型肝炎病毒感染者胃粘膜病变的影响

目的通过研究慢性乙型肝炎病毒感染者胃粘膜及血清中乙肝病毒标志物的存在情况,以探讨乙型肝炎病毒感染对慢性乙型肝炎病毒感染者胃黏膜病变的影响。方法对60例慢性乙型肝炎病毒感染者用酶联免疫吸附法(ELISA)检测血清中HBsAg、HBeAg、anti-HBs、anti-HBC、anti—HBC,免疫组织化学法(Envision)检测胃黏膜组织中FIBsAg、HBcAg。结果 60例慢性乙型肝炎病毒感染者中出现胃黏膜病变56例。胃黏膜组织中HBsAg和(或)HBcAg阳性29例,其中20例病变以中、重度为主(占68.97%):慢性乙型肝炎病毒感染者胃黏膜组织中HBsAg、HBcAg检测阳性者胃黏膜病变的程度较重;胃黏膜病变程度与血清中HBVM分布无关。结论乙型肝炎病毒可侵犯胃黏膜组织。并可在其中复制,可能是导致慢性乙型肝炎病毒感染者胃黏膜病变的一个重要因素:胃黏膜病变程度与胃黏膜乙型肝炎病毒感染密切相关。

Objective To nvestigate the correI ation among hepatitjs Bvi;rus markers（HBVM）i n serum and gast ric mucosa in chronic patients with hepatitis B vi rus infection the influence of HBV infect ion on gast ric mucosa in chron ic hepat its B pat ients.Methods：60 pat ients with chronIc HBV i nfection diagnosed by se rum HBV DNA examinat ion were enrol led ln thi s study.HBVM in Serum were determined with ELISA whi Ie HBsAg and HBcAg in gast ric mucosa were detected by immunohistochemistry.RlesuIts：The damage of gastric mucosa was found i n 56 of 60 patients.I n 20 0f 29 cases with HBcAg and（or）HBsAg ln the gastricmucosa.there were moderate and severegast ric damage.The damage of the gast ric mucosa in the patients with positive findings of HBVM in the gastric mucosa was serious.The damage of the gastric mucosa has no cor relation with the HBVM in the serum.Conclusions：HBV may grow and copy in gastric mucosa。maybe it is an important factor of gastric mucosales ions in chronic patients with HBV infection.The damage of gastrlc mucosa in the patients with HBV infection is correIation with the infection of HBV in the gastric mucosa.