主动免疫治疗复发性流产58例疗效分析

Active immunity treatment for recurrent spontaneous abortion:a curative effect analysis of 58 cases

目的:观察采用淋巴细胞对复发性流产进行主动免疫的疗效。方法:58例原因不明复发性流产患者检测封闭抗体阴性后,采用配偶外周血淋巴细胞进行主动免疫治疗。结果:妊娠成功49例,成功率为84.5%;3例未孕(仍在治疗中),2例治疗3次后失访,1例宫外孕,3例流产(其中1例双胎妊娠至6个月流产)。结论:主动免疫对于原因不明复发性流产患者是一种安全、有效的治疗方法,能进一步提高妊娠成功率。

Objective：To observe the effect of lymphocyte immunization therapy for recurrent spontaneous abortion（RSA）. Methods： Fifty-eight cases of unexplained RSA detected with negative blocking antibody were treated with peripheral blood lymphocytes from spouse for active immunotherapy. Results：Forty-nine patients （84.5 % ） were pregnanted successfully. Three patients were failed （still in treatment） ,2 cases were lost to follow up after the third treatment, one case was ectopic pregnancy, and 3 cases were aborted （including 1 case of twin pregnancy to six months）. Conclusions ： Allogeneic immunotherapy on patients with unexplained RSA may be a safe effective treatment,it can furtherly improve the success rate of pregnancy.