内脂素与子痫前期

Relationship Between Visfatin and Pre-eclampsia

内脂素(visfatin)是新近发现的一种主要由内脏脂肪细胞分泌的脂肪因子,结构复杂,存在基因多态性,具有调节糖脂代谢作用。内脂素增加胰岛素敏感性、促进血管平滑肌细胞成熟、参与炎症反应及血管生成,与动脉粥样硬化形成及血管内皮细胞受损和功能紊乱密切相关。子痫前期是一种病因不明的病理妊娠,严重危害母婴生命,血管内皮细胞损伤和功能紊乱可能是导致子痫前期最终发病并出现临床表现的根本原因。推测内脂素可能通过多种途径参与子痫前期的发病。内脂素已成为当前研究热点之一。

Visfatin is a newly discovered one of the main visceral fat factors secreted by fat cells,with complicated structure and genetic polymorphism,which can regulate glucose and lipid metabolism,increasing insulin sensitivity,promoting vascular smooth muscle cell maturation,involving in inflammatory response and angiogenesis,and formation of atherosclerosis and vascular endothelial cell damage and dysfunction.Pre-eclampsia is a pathology of unknown cause in pregnancy,seriously endanger the life of mother and child,vascular endothelial cell injury and dysfunction may lead to the ultimate incidence of pre-eclampsia and the emergence of the root causes of the clinical manifestations.People speculated that visfatin may be involved in a variety of ways to the pathogenesis of pre-eclampsia,as one of the focuses of current research.