血小板活化与妊娠期高血压疾病的研究进展

Progress in Platelet Activation and Hypertensive Disorder Complicating Pregnancy

妊娠期高血压疾病是妊娠期特有的疾病,多发生于妊娠20周后,在中国妊娠妇女中的平均发病率高达9.4%,严重危害母婴健康,是造成孕产妇死亡的第二大原因。其发病机制尚未完全明确,与血管内皮损伤,凝血、纤溶系统亢进,抗凝血功能减退及血小板功能状态改变有关。血小板是血液循环中最小的无核细胞成分,当某种因素成为刺激血小板的活化因子时,可导致血小板的活化、释放分泌活性物质、黏附和聚集,形成血小板血栓。近年研究显示,血小板的活化、黏附、聚集等功能的改变参与了妊娠期高血压疾病的发生、发展过程。现综述血小板活化与妊娠期高血压疾病的研究进展。

The hypertensive disorder happened in pregnancy after 20 weeks,in China the average morbidity was 9.4%;it could be the second reasons which leads to death of the pregnant women.The pathogenesis had not yet completely clear,it might relate to vascular endothelial injury,activation of coagulation,fibrinolysis system and platelet dysfunction.Platelets were the smallest and non-nuclear components in the blood,when activated the platelet secretion,adhesion and aggregation then made up the platelet thrombus.In the recent years,lots of studies had shown that the activation,adhesion,aggregation and other functional changes of platelet played an important role in the progress of the disease.This article summarizes the research progress in platelet activation and hypertensive in pregnancy.