摘要
微小RNA(microRNA,miRNA)是动、植物基因组中广泛存在的一类非编码单链小分子RNA,在转录后水平以完全或非完全互补的方式与其靶mRNA相结合,调节靶mRNA表达,从而影响生物学性状。研究发现,miRNA参与生命过程中一系列重要进程,参与人体生理或病理过程,与人类多种疾病密切相关。目前,关于miRNA在妇科恶性肿瘤中的研究仍处于起步阶段。大量研究发现,miRNA在肿瘤不同阶段表达不同,提示miRNA在恶性肿瘤的发生、诊断、治疗及预后起重要作用,但其具体作用机制仍不清楚,其临床应用价值仍有待进一步研究。
MicroRNA is a kind of non-coded single stranded micromolecule RNA,generally existing in animal、plant genome.It integrates with its target mRNA by means of complete or incomplete complementary method in post-transcriptional level to regulate the expression of target mRNA,and then affects biological character.Update study and research show that,miRNA participates a series of important process in vital process,and also correlates closely with human disease.miRNA plays an important role of genesis,diagnosis,therapy and prognosis of malignant tumors.
出处
《国际妇产科学杂志》
CAS
2011年第3期234-236,252,共3页
Journal of International Obstetrics and Gynecology
关键词
微RNAS
宫颈肿瘤
子宫内膜肿瘤
卵巢肿瘤
癌
MicroRNAs
Uterine cervical neoplasmas
Endometrial neoplasmas
Ovarian neoplasmas
Carcinoma