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微小RNA在妇科恶性肿瘤中的研究进展 被引量：2

Progress in Study of MicroRNA in Gynecological Malignant Tumor
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摘要 微小RNA(microRNA,miRNA)是动、植物基因组中广泛存在的一类非编码单链小分子RNA,在转录后水平以完全或非完全互补的方式与其靶mRNA相结合,调节靶mRNA表达,从而影响生物学性状。研究发现,miRNA参与生命过程中一系列重要进程,参与人体生理或病理过程,与人类多种疾病密切相关。目前,关于miRNA在妇科恶性肿瘤中的研究仍处于起步阶段。大量研究发现,miRNA在肿瘤不同阶段表达不同,提示miRNA在恶性肿瘤的发生、诊断、治疗及预后起重要作用,但其具体作用机制仍不清楚,其临床应用价值仍有待进一步研究。 MicroRNA is a kind of non-coded single stranded micromolecule RNA,generally existing in animal、plant genome.It integrates with its target mRNA by means of complete or incomplete complementary method in post-transcriptional level to regulate the expression of target mRNA,and then affects biological character.Update study and research show that,miRNA participates a series of important process in vital process,and also correlates closely with human disease.miRNA plays an important role of genesis,diagnosis,therapy and prognosis of malignant tumors.
作者 李翔 鲁艳明 张淑兰
机构地区 中国医科大学附属盛京医院妇产科
出处 《国际妇产科学杂志》 CAS 2011年第3期234-236,252,共3页 Journal of International Obstetrics and Gynecology
关键词 微RNAS 宫颈肿瘤 子宫内膜肿瘤 卵巢肿瘤 癌 MicroRNAs Uterine cervical neoplasmas Endometrial neoplasmas Ovarian neoplasmas Carcinoma
分类号 R737.33 [医药卫生—肿瘤]
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参考文献13

  • 1Lee RC ,Feinbaum RL,Ambros V.The C. elegans heterochomic gene lin-4 encodes small RNAs with antisense complementarily to lin-14 [J ]. Cell, 1993,75 (5) : 843-854.
  • 2Lee Y, Ahn C, Han J, et al. The nuclear RNase III Drosha initiates microRNA processing [ J ]. Nature, 2003,425 ( 6956 ) : 415 -419.
  • 3Wang X,Tang S, Le SY, et al. Aberrant expression of oncogenic and tumor-suppressive micreRNAs in cervical cancer is required for cancer cell growth [J ]. PLoS One, 2008,3 (7) : e2557.
  • 4Lee JW,Choi CH,Choi JJ,et al. Altered MicroRNA expression in cervical carcinomas [J]. Clin Cancer Res,2008,14 (9):2535- 2542.
  • 5Tang G,Reinhart BJ ,Bartel DP,et al. A biochemical framework for RNA silencing in plants [ J ]. Genes Dev,2003,17 ( 1 ) :49-63.
  • 6Dalmay T. MicroRNAs and cancer [J]. J Intern Med,2008,263 (4) : 366-375.
  • 7Lewis BP,Burge CB,Bartel DP. Conserved seed pairing,often flanked by adenosines, indicates that thousands of human genes aremicroRNA targets[J]. Cell ,2005,120( 1 ) : 15-20.
  • 8Nam EJ,Yoon H,Kim SW,et al. MicroRNA expression profiles in serous ovarian carcinoma [ J ]. Clin Cancer Res,2008,14 (9) : 2690- 2695.
  • 9Bemstein E,Caudy AA,Hammond SM,et al. Role for a bidentate fibonuclease in the initiation step of RNA interference [J ]. Nature, 2001,409(6818) :363-366.
  • 10Hu X,Schwarz JK, Lewis JS Jr,et al. A microRNA expression signa- ture for cervical cancer prognosis[J]. Cancer Res,2010,70(4): 1441-1448.

同被引文献39

  • 1Ili CG,Brebi P,López J. Genotyping of human papillomavirus in cervical intraepithelial neoplasia in a high-risk population[J].Journal of Medical Virology,2011,(05):833-837.
  • 2Lee RC,Feinbaum RL,Ambros V. The C.elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14[J].CELL,1993,(05):843-854.
  • 3Huang L,Lin JX,Yu YH. Downregulation of six microRNAs is associated with advanced stage,lymph node metastasis and poor prognosis in small cell carcinoma of the cervix[J].PLoS One,2012,(03):e33762.
  • 4Zhou X,Chen X,Hu L. Polymorphisms involved in the miR-218-LAMB3 pathway and susceptibility of cervical cancer,a case-control study in Chinese women[J].Gynecologic Oncology,2010,(02):287-290.
  • 5Pang RT,Leung CO,Ye TM. MicroRNA-34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells[J].CARCINOGENESIS,2010,(06):1037-1044.
  • 6Wang X,Meyers C,Guo M. Upregulation of p18Ink4c expression by oncogenic HPV E6 via p53-miR-34a pathway[J].International Journal of Cancer,2011,(06):1362-1372.
  • 7Wilting SM,van Boerdonk RA,Henken FE. Methylation-mediated silencing and tumour suppressive function of hsa-miR-124 in cervical cancer[J].Molecular Cancer Therapautics,2010.167.
  • 8Li BH,Zhou JS,Ye F. Reduced miR-100 expression in cervical cancer and precursors and its carcinogenic effect through targeting PLK1 protein[J].EUROPEAN JOURNAL OF CANCER,2011,(14):2166-2174.
  • 9López JA,Alvarez-Salas LM. Differential effects of miR-34c-3p and miR-34c-5p on SiHa cells proliferation apoptosis,migration and invasion[J].Biochemical and Biophysical Research Communications,2011,(03):513-519.
  • 10Wang F,Li Y,Zhou J. miR-375 is down-regulated in squamous cervical cancer and inhibits cell migration and invasion via targeting transcription factor SP1[J].AMERICAN JOURNAL OF PATHOLOGY,2011,(05):2580-2588.

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国际妇产科学杂志
2011年 第3期

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