二茂铁功能化的水溶性金纳米粒子的合成与表征

Preparation and Characterization of Ferrocene-functionalized and Water-soluble Gold Nanoparticle

以聚乙二醇(PEG)为原料,经4步反应合成了一种端基为二茂铁(FcH)的PEG硫醇配体(Fc-PEG-SH)。采用两相法制备了油胺(OAm)保护的金纳米粒子(OAm/nanoAu)。采用配体交换法合成了二茂铁功能化的水溶性金纳米粒子(Fc-PEG/nanoAu),其结构和性能经UV-Vis,1HNMR,IR,TGA,XPS,TEM及循环伏安法表征和分析。结果表明:Fc-PEG/nanoAu粒径为4 nm,且分散性良好;氧化电位较Fc-PEG-SH降低。

PEG mercaptan ligand with ferrocene end-group（Fc-PEG-SH） was synthesized from polyglycol（PEG） by a four-step reaction.Oleylamine（OAm） coated gold nanoparticles（OAm/nanoAu） were prepared by two-phase method.A ferrocene-functionalized and water-soluble gold nanoparticle（Fc-PEG/nanoAu） were synthesized by the ligand-exchange method.The structures and performance of gold nanoparticle were characterized by UV-Vis,1H NMR,IR,TGA,XPS,TEM and cyclic voltammetry.The results showed that the particle size of gold nanoparticle were 4 nm,dispersion property were good,and oxidation peak current was increased.