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润通舒对烫伤大鼠肠黏膜屏障功能的保护作用研究 被引量:1

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摘要 目的观察滋阴活血润肠药润通舒对严重烫伤后肠黏膜屏障的保护作用。方法 SD大鼠70只随机分成3组,滋阴活血润肠法治疗组(润通舒组)30只,单纯烫伤组(对照组)30只,制备成大鼠烫伤模型,分别予以润通舒、生理盐水灌胃;另正常组10只,不作处理。均检测血浆内毒素水平、肠黏液SIgA质量浓度及回盲部黏膜菌群等。结果润通舒可明显降低烫伤模型大鼠内毒素水平,增加肠道SIgA的合成与分泌,提高肠道双歧杆菌量,减少肠道大肠埃希菌和真菌量。结论滋阴活血润肠药润通舒能促进烫伤后受损的肠黏膜免疫屏障和生物屏障的修复,有效防治肠道内毒素易位。
出处 《中国中医急症》 2011年第7期1090-1090,1096,共2页 Journal of Emergency in Traditional Chinese Medicine
基金 湖南省科技厅基金资助项目(05FJ3022)
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