抗骨增生片对兔骨关节炎滑膜病理形态及uPA、uPAR表达的影响

Effect of Kangguzengsheng Tablet on Synovium Pathomorphology and Expressions of uPA and uPAR in Rabbits with KOA

目的探讨抗骨增生片治疗骨关节炎是否与改变滑膜组织形态以及下调尿激酶型纤溶蛋白酶原激活物(uPA)及其受体(uPAR)的表达有关。方法 30只健康雄性日本大耳白兔随机分成正常对照组、模型对照组,抗骨增生片组。用1.6%木瓜蛋白酶膝关节腔内注射,建立兔膝骨关节炎模型。灌胃4周后,观察滑膜组织病理形态学变化,免疫组织化学法测定uPA、uPAR的表达情况。结果抗骨增生片组滑膜组织病理总积分明显低于模型对照组;抗骨增生片组uPA、uPAR的表达低于模型对照组。结论抗骨增生片治疗膝骨关节炎可能与抑制uPA、uPAR的表达,抑制滑膜炎症的进一步发展,修复滑膜损害有关。

Objective：To explore whether the effect of Kangguzengsheng Table is related to the synovium conformation change and the decrease of uPA and uPAR.Methods：30 healthy male rabbits were randomly divided into the normal control group,the model control group and the Kangguzengsheng Tablet group.The KOA model were induced by injection 1.6% papain into the cavum articulare.After intragastric administration for 4 weeks,the synovium pathomorphology change and the expressions of uPA and uPAR were observed.Results：The pathological score of synovium and the expressions including uPA and uPAR in the Kangguzengsheng Tablet group were lower than those of the model control group significantly.Conclusion：The therapeutical effect of Kangguzengsheng Tablet to KOA is possible related to inhibition of expressions including uPA,uPAR and rehabilitation synovium injury.