关节炎大鼠模型血清中IL-4、IL-10表达的检测

Detection on Expression of IL-4 and IL-10 in Adjuvant Arthritis Rats Models

目的检测白细胞介素-4(IL-4)、白细胞介素-10(IL-10)在佐剂性关节炎(AA)大鼠模型血清中的水平。方法建立AA大鼠模型,根据X线片及组织病理学的特点证实造模成功。用ELISA法检测AA大鼠模型血清中炎性细胞因子IL-4、IL-10的水平。结果与对照组大鼠比较,模型组大鼠血清中IL-4、IL-10水平明显降低。结论模型组大鼠血清中含有少量的IL-4、L-10,提示在类风湿关节炎的发病过程中IL-4、IL-10的分泌受到了抑制。

Objective：To detect the expressions including IL-4 and IL-10 in adjuvant arthritis（AA） rats models.Methods：After the AA rats models were established,the IL-4 and the IL-10 were determined by ELISA method.Results：Compared with the control group,the IL-4 and the IL-10 were decreased obviously.Conclusion：That there are small amounts of IL-4 and IL-10 is indicating that IL-4 and IL-10 are inhibit in the RA onset period.