海松欣颗粒制备工艺的研究

Research on Haisongxin granules preparation process

为优化海松欣颗粒的制备工艺,本文采用正交实验法,以总糖含量、还原糖含量及干浸膏得率为指标,筛选最佳提取工艺;以颗粒的吸湿百分率、成型率和溶化率为指标,筛选颗粒辅料的最佳配比。得到海松欣颗粒最佳提取工艺为:加8倍量水,提取3次,每次1.5 h。制粒的最佳处方为:1份浸膏粉与2份辅料(糖粉∶糊精=1∶1)。实验结果证明,该工艺科学、合理、可行。

We employed the orthogonal experimental approach and took the content of total sugar,reducing sugar and the yield of extraction as measurement indices to select the optimum extraction process of Haisongxin granules.We selected the optimum ingredient ratio of their excipients according to hygroscopicity,granulation and dissolubility.The acquired optimal extraction process of Haisongxin granules is adding eight times the amount of water and extracting three-times,1.5 hours each time.The optimum formula is one portion of extract powder and two portions of excipients whose ingredient ratio is 50% sucrose and 50% dextrin.Experimental results show that this process is scientific,reasonable and feasible.