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凉味剂薄荷甘油醚的合成研究 被引量：1

Synthesis of Coolant Agent of Menthol Glyceryl Ether
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摘要 以薄荷脑为起始原料,先与环氧氯丙烷在无水三氯化铝催化作用下,反应制得1-氯-3-薄荷氧基-2-丙醇,然后经酯化、水解反应获得凉味剂薄荷甘油醚.三步反应总得率为71.3%,产品经色质分析证明其结构与薄荷甘油醚相符.该合成方法原料价廉易得、反应得率高、适合工业化生产. L-Methyl glyceryl ether was synthesized from L-menthol and Epichlorohydrin by three steps. The total yield was 71.3%. The structure of Menthol glyceryl ether obtained was confirmed by GC-MS. This synthetic method had some advantages, such as cheap raw material and high yield, which is suitable for commercial production.
作者 马洪亮 吴奇林 李锐 莫东升
机构地区 深圳波顿香料有限公司
出处 《北京工商大学学报（自然科学版）》 CAS 2011年第3期13-15,共3页 Journal of Beijing Technology and Business University:Natural Science Edition
关键词 薄荷脑 薄荷甘油醚 凉味剂 menthol menthol glyceryl ether coolant agent
分类号 TS201.2 [轻工技术与工程—食品科学] TS201.1 [轻工技术与工程—食品科学]
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参考文献7

  • 1中华人民共和国卫生部,中国国家标准化管理委员会发布,GB2760-2007,食品添加剂使用卫生标准[S].北京:中国标准出版社,2008.
  • 2Ishida M, Aida T, Matsuda H. Menthyl glyoxylates, their compositions for imparting refreshing feeling and for sensory stimulation, and use of the sensory stimulant compositions: JP, 2005 343 795[P]. 2005 - 12- 15.
  • 3Estanislao R B, Lambino D L, Lim C, et al. Product for administration of active agents to different areas of the skin: US, 2005 0074484[P]. 2005 -04-07.
  • 4Kiefer J, Harvey J E. Cooling compositions: US, 2007 077 331[P]. 2007-04-05.
  • 5Amano Akira, Moroe Michio, Yoshida Toshio. 3-Levo- Menthoxypropane-1,2-diol: US, 4459 425 [ P]. 1984 - 07 - 10.
  • 6章平毅,毛海舫,沈蔚,陆欢.凉味剂3-L-薄荷氧基丙烷-1,2-二醇的合成研究[J].化学世界,2008,49(7):415-418. 被引量：1
  • 7AmanoA, TokoroK. (2S)-3-{(1R,2S,5R)-[5-methyl- 2-( 1-methylehtyl )-cyclohexyl I oxy }-1, 2-propanediol, Process for producting the same, and compositons containing the same: US, 5608 l19[P]. 1997-03 -04.

二级参考文献11

  • 1GB2760-1996《食品添加剂使用卫生标准》[S]．
  • 2Kiefer J, Harvey J E. Cooling eompositions[P]. US: 2007 077 331. 2007-04-05.
  • 3Estanislao R B, Lambino D L, Lim C, etal. Product for administration of active agents to different areas of the skin[P]. US:2005 0 074 484, 2005-04-07.
  • 4Ishida M, Aida T, Matsuda H. Menthyl glyoxylates, their compositions for . imparting refreshing feeling and for sensory stimulation, and use of the sensory stimulant compositions [P]. JP: 2005 343 795, 2005-12-15.
  • 5Ishida K, Aida T, Matsuda H, et at. Menthol derivative and cooling agent composition comprising the same[P]. WO:2005 115 325, 2005-12-08.
  • 6Fujii M, Takeda Y, Yoshida M, et al. Comparison of skin permeation enhancement by 3-L- menthoxypropane-1, 2-diol and L-menthol: the permeation of indomethacin and antipyrine through Yucatan micropig skin and changes in infrared specta and x-ray diffraction patters of strarum corneum[J]. International Journal Of Pharrnaceutics, 2003, 258(1- 2) : 217:223.
  • 7Matias J R. Methods of using menthol propyleneglycol-carbnate and analogs thereof for producing anti-inflammatory and anti-angiogenic effects[P]. WO:2006 034 495, 2006-03-30.
  • 8Amano A, Moroe M, Yoshida T. 3-Levomenthoxypropane-1,2-diol[P]. US:4 459 425, 1984- 07-10.
  • 9Amano A, Tokoro K. (2S)-3-[(1R,2S, 5R)-[-5- methyl-2-(1-methyiethyl )-cyClohexyl ] oxy ]-1, 2- propanediol, Process for producing the same, and compositions containing the same[P]. US: 5 608 119, 1997-03-04.
  • 10Amano A, Akiyama T, Miura T, et al. Method for producing 3-L-menthoxypropane-1,2-diol[P]. US: 6 515 188,2003-02-04.

共引文献17

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二级引证文献3

北京工商大学学报（自然科学版）
2011年 第3期

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