临床药师对Ⅰ类切口手术预防用抗菌药物干预效果分析

Analysis of the Effect of Clinical Pharmacists′ Intervention in Antibiotics Used for Type I Incision Surgical Prevention

目的验证临床药师对外科预防使用抗菌药物进行干预的效果。方法以临床药师督查记录数据为基础,将2010年1～3月238份病历设为非干预组,2010年10～12月240份病历设为干预组,建立评价标准,进行回顾性汇总、分析。结果通过干预,抗菌药物使用率从干预前的100%下降为77.08%(χ2=63.633,P=0.000),抗菌药物联用情况减少(χ2=53.712,P=0.000),用药时机和用药疗程有了较大改善,抗菌药物费用下降(t=-5.235,P=0.000),住院医疗费用降低(t'=-12.280,P=0.000),住院天数减少(t=-5.071,P=0.000)。结论临床药师通过实施合理用药干预对促进医院安全、有效、经济使用抗菌药物起到了积极作用。

Objective To verify the effect of clinical pharmacists＇ intervention in antibiotics used for Type I incision surgical prevention.Methods Based on the supervision and inspection recording data of clinical pharmacists,we arranged 238 medical records in the first quarter of 2010 as non-intervened group and 240 medical records in the fourth quarter of 2010 as intervened group,and then established evaluation criteria and conducted a retrospective study for analysis.Results Through intervention,the rate of using antibiotics decreased from the previous 100% to 77.08%（χ2=63.633,P=0.000）,the use of combined antibiotics also decreased（χ2=53.712,P=0.000）,the time of course of using antibiotics improved,medical expenses of the antibiotics were reduced（t=-5.235,P=0.000）,hospitalization cost decreased（t=-12.280,P=0.000）,and hospital stay was shortened（t=-5.071,P=0.000）.Conclusion Clinical pharmacists＇ intervention in rational use of drugs play a positive role in contribution to a safe,effective and economical application of antibiotics.