早期上皮性卵巢癌的临床与预后

Clinical Features and Prognosis of Early Epithelial Ovarian Cancer

【目的】分析早期上皮性卵巢癌的临床特点、预后及其影响因素，探讨早期患者的理想治疗方案。【方法】回顾性分析1993-1998年间湖南省肿瘤医院治疗的60例早期上皮性卵巢癌患者的临床资料。【结果】患者平均年龄41岁，≤35岁22例，占36．7％。多因素分析显示FIG0分期及组织病理分级是独立预后因素。FIG0IAB期患者的5年及10年生存率分别为100％及96．4％，显著高于FIGOIc及Ⅱ期患者（P〈0．01）。病理学分级为低分化（G。）患者的5年及10年生存率均为58．0％，显著低于中分化（G：）及高分化（G。）患者（P〈O．05）。【结论】早期上皮性卵巢癌年轻患者比例高，预后好，保留生育功能是可考虑的选择。对FIGOIc和Ⅱ期患者及组织学分化不良的患者需辅助化疗。

[Objective] To analyze the clinical features, prognosis and the influential factors of early ovari- an cancer in order to explore the ideal treatment of early patients. [Methods] The clinical data, the treatment method and prognosis of 60 patients with early epithelial ovarian cancer in Hunan Tumor Hospital from 1993 to 1998 were analyzed retrospectively. [Results] The mean age of patients was 41 years, of which 22 cases （36.7%） was younger than 35 years. Multiple factor analysis showed that FIGO stage and histological grade were the independent prognostic factors. The overall 5-year and 10-year survival rate of patients with FIGO stage I A-B were 100% and 36.4%, respectively, which were significantly higher than those of patients with FIGO stage I C and II （ P 〈0. 01）. The overall 5-year and 10-year survival rate of patients with histological grade 3（G3） were 58.0% which were significantly lower than those of patients with histological grade 2（G2 ） and grade I（G1） （ P 〈0.05）. [Conclusion] The young patients with early epithelial ovarian cancer has high proportion and good prognosis. Fertility preservation should be considered for early young patients. Adjuvant chemotherapy should be given for patients with FIGO stage I C , II and low histological differentiation.