骨桥蛋白及其受体异常表达在子宫内膜异位症中的作用

The role of the abnormal expression of osteopontin and integrin αvβ3 on the patients with endometriosis

目的探讨骨桥蛋白(OPN)及其受体整合素αvβ3在子宫内膜异位症发生、发展中的作用。方法随机选取经手术治疗的89例子宫内膜异位症患者的异位和在位内膜作为实验组,同期非内异症患者子宫内膜作为对照组,SP免疫组化法对上述病例的骨桥蛋白及其受体整合素αvβ3的表达水平进行检测;并对两者进行相关性分析。结果子宫内膜异位症患者的异位内膜中骨桥蛋白及其受体整合素αvβ3的表达高于其在位内膜的表达,子宫内膜异位症患者的在位内膜中骨桥蛋白及其受体整合素αvβ3的表达高于对照组子宫内膜中的表达;骨桥蛋白及其受体整合素αvβ3两者在子宫内膜异位症中的表达呈正相关。结论在子宫内膜异位症中存在着OPN、整合素αvβ3的高表达,两者可能协同在子宫内膜异位症的发生发展中起着重要作用。

Objective To explore the role of osteopontin and integrin αvβ3 on the pathogenesis of endometriosis. Methods 89 cases with endometriosis by surgery were randomly chosen. Immunohistoehemisty was used to detect the expression of OPN and integrin αvβ3 in eutopic and ectopic endometrium. The same detection was used to the normal endometrium of the patients without endometriosis during the same period as control. The relationship between OPN and integrino αvβ3 was also explored. Results OPN was mainly expressed in endometrial glandular cells. OPN and integrin αvβ3 expressions in ectopic endometrium of the patients with endometriosis were significantly higher than that in eutopic endomerium. There was great difference of OPN and integrinc αvβ3 expression between eutopic and normal endometrium. OPN and integrin αvβ3 were related in endometriosis. Conclusion The study showed significantly higher expression of integrin β3 and OPN in endometriosis, which may be related to the pathogenesis and development of endometriosis.