VEGF与Ki-67在甲状腺乳头状癌中的表达及临床意义

Expressions of VEGF and Ki-67 in papillary thyroid carcinoma and their clinical significance

目的:探讨甲状腺乳头状癌组织中VEGF、Ki-67蛋白表达与其临床病理的关系。方法:应用免疫组化SP法,对55例甲状腺乳头状癌组织中VEGF、Ki-67蛋白进行检测。结果:甲状腺乳头状癌组VEGF蛋白阳性表达率为52.7%(29/55),Ki-67增殖指数为(11.07±3.84)%。VEGF蛋白的阳性率、Ki-67增殖指数随着肿瘤分化程度降低、淋巴结转移、被膜的侵犯逐渐增加。结论:VEGF、Ki-67蛋白表达异常可能在甲状腺乳头状癌发生或发展中起一定作用。VEGF、Ki-67蛋白的联合检测对甲状腺乳头状癌的早期诊断、预后的判断及对制定合理治疗方案有重要的临床应用价值。

Objective：To investigate the relationship between the expression of VEGF,Ki-67 proteins and clinicopathology of human papillary thyroid carcinoma.Methods：Using SP immunohistochemical methods,the expression of VEGF and Ki-67 proteins was detected in 55 cases of papillary thyroid carcinoma.Results：The positive rate of VEGF protein expression was 52.7%（29 / 55）and Ki-67 proliferative index was（11.07±3.84）% in papillary thyroid carcinoma.The positive rate of VEGF protein expression and Ki-67 proliferative index increased with the decrease of pathological grade,and the increase of lymph node metastasis and capsule invasion.Conclusion：The abnormal expression of VEGF and Ki-67 proteins might play an important role in the pathogenesis and development of papillary thyroid carcinoma.It has an important clinical value for early diagnosis,prognosis evaluation and proper treatment of papillary thyroid carcinoma to determine the expression of VEGF and Ki-67 proteins simultaneously.