螺内酯对快速起搏家兔心房电重构的影响

Effect of Spironolactone on Electrical Remodeling Induced by Rapid Atrial Pacing in Rabbits

目的观察醛固酮受体拮抗剂——螺内酯对快速心房起搏家兔心房电重构的影响。方法将30只家兔随机分为3组,对照组、快速起搏组及螺内酯组各10只。经颈内静脉将心房电极置入右心房。分别测量起搏开始前、起搏开始后1h、2h、4h、6h、8h分别记为(P0、P1、P2、P4、P6、P8)时的心房有效不应期(AERP200和AERP150)。结果快速起搏组在不同基础刺激作用下AERP缩短,AERP200-AERP150频率适应性不良,P8与起搏前P0比较差异有统计学意义(P<0.05),螺内酯组AERP缩短较快速起搏组减轻,频率适应性得以维持(P>0.05)。结论螺内酯可以抑制快速心房起搏所致电重构。

Objective To investigate the effects of spironolactone on the electrical remodeling induced by rapid intra-atrial pacing in rabbits. Methods Thirty rabbits were randomly assigned into 3 groups ： control group （ n = 10）, rapid pacing group （ n = 10） and spironolactone group（ n = 10）. The atrial lead was placed in the right atrium by right internal jugular vein approach. The atrial effective refractory period（AERP） was measured before pacing and 1,2,4,6 ,and 8 hours after the onset of the pacing. Results In the rapid pacing group,the AERP was shortened, and the adaption rate of AERP lost during pacing as compared with those before pacing（P 〈 0.05 ）. The shortening of AERP was attenuate and the adaption rate was maintained in spironolactone group （ P 〉 0.05）. Conclusion Spironolactone can inhibit the atrial electrical remodeling.