B超测NT联合母体血清AFP、F-β-HCG筛查胎儿唐氏综合征的临床价值分析

Detecting Nuchal Skinfold Thickness and Maternal Serum AFP and Free-β-HCG in Screening fetuses with Down syndrome

目的探讨B超测胎儿颈部软组织厚度联合母体血清标记物在筛查胎儿发育异常的临床应用价值。方法收集300例孕11～14周超声测定胎儿颈部软组织(nuchal translucency,NT)厚度;600例孕14～21周测定母体二联血清标记物(AFP+Free--βHCG);300例在孕11～14周既超声测定胎儿颈部软组织又于孕14～21周测定母体二联血清标记物的参加者。对其胎儿结局进行追踪。结果胎儿NT测定和母体血清标记物用于筛查胎儿发育异常的敏感度分别为75%和90.9%,特异度分别为99.3%和92.6%。胎儿NT测定联合母体血清标记物用于筛查胎儿发育异常的敏感度为100%,特异度为85.1%。结论胎儿NT和母体血清标记(AFP+Free-β-HCG)筛查胎儿发育异常具有较高的敏感性。两者联合敏感度更加显著。

Objective To investigate the value of combined detecting nuchal skinfold thickness（NT） of fetus with maternal serum AFP and F-β-HCG.Methods The NTs were detected in 300 fetus with the gestational age being 11 to 14 weeks by ultrasonography,while the maternal serum AFP and F-β-HCG were tested in 600 pregnant women with the gestational weeks of 14 to 21.Other 300 cases received NT detection at 11 to 14 weeks and maternal serum AFP and F-β-HCG tests at 14 to 21 weeks.The fetal outcomes were followed up.Results For screening the fetal abnormalities,the sensitivities of NT and maternal serum markers were 75% and 90.9%,respectively;the specificities were 99.3% and 92.6%,respectively.The sensitivity and specificity of combined determination of fetal NT with maternal serum screening marker were 100% and 85.1%,respectively.Conclusion There are high sensitivity for screening fetal abnormalities with determination of fetal NT and maternal serum markers（AFP＋Free-β-HCG）.The combined detection of the two methods can improve the sensitivity significantly.