期刊文献+

茴拉西坦分散片制备及体外溶出度影响因素考察

Preparation of Aniracetam Dispersed Tablets and study on the influencing factors of dissolution in vitro
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摘要 目的制备茴拉西坦分散片(ADT),考察其体外溶出特性和影响溶出度的因素。方法采用正交试验设计方案,以溶出度为考察指标,对茴拉西坦分散片进行处方筛选,考察可能影响溶出度和分散均匀性的因素。结果按优化处方制备的分散片溶出较好,分散较快。结论优选处方制备的茴拉西坦分散片溶出度好,影响其溶出度的主要因素为PVPP、L-HPC用量和PVP K30浓度。 Objective To prepare Aniracetam Dispersed Tablets(ADT),and study the character of its dissolution in vitro and the influencing factors of dissolution.Methods The orthogonal design was used and taken dissolution as indices to screen the ADT prescription,the possible influence factors of dissolubility and the disperse uniformity were studied.Results The dissolution of the optimized ADT prescription was better and disintegrated quickly.Conclusion The optimized ADT prescription disintegrated faster than normal Aniracetam Tablets.The main influencing factors of dissolution were the amount of PVPP and L-HPC and the concentration of PVP K30.
出处 《齐鲁药事》 2011年第6期316-317,共2页 qilu pharmaceutical affairs
关键词 茴拉西坦 分散片 正交试验 溶出度 Aniracetam Dispersed tablets Orthogonal experiment Dissolution
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