血浆脑钠肽与心力衰竭患者心脏功能指标的相关性研究

Correlation between Plasma Level of Brain Natriuretic Peptide and Cardiac Functional Parameter in Patients with Congestive Heart Failure

目的探讨血浆脑钠肽（BNP）水平与心力衰竭（CHF）患者心功能的相关性及其临床意义。方法用化学发光免疫分析法测定26例CHF患者（CHF组,心功能Ⅱ~Ⅳ级）及21例体检正常者（对照组）血浆BNP的水平,超声心动图测定CHF组及对照组左室射血分数（LVEF）和心脏指数（CI）。结果心力衰竭患者血中BNP水平明显高于正常对照组（P〈0.01）,并随着心功能纽约分级（NYHA）程度的加重而显著增加（P〈0.01）,与左室射血分数（LVEF）呈负相关（r=-0.409,P〈0.01）,与心脏指数（CI）呈负相关（r=-0.483,P〈0.01）。结论血浆BNP水平是反映心力衰竭患者心功能受损的敏感指标,可以作为诊断心力衰竭的一个很好指标。

Objective To estimate the diagnostic value of plasma brain natriuretic peptide（BNP） in patients with congestive heart failure and the relationship with cardiac functional parameter. Methods Plasma BNP concentration of patients with CHF（CHF group,n=26） and those of normal controls（control group,n=21） were measured by chemiluminescent immunoassay.Left ventricular ejection fraction and cardiac index were measured by echocardiography. Results The plasma BNP concentration of patients in CHF group were significantly higher than those in control group（P0.01）,they also increased according to the severity of heart failure classified by NYHA.The plasma BNPlevel in CHF group had a positive correlation with LVEF and CI.（r=-0.409,P0.01、r=-0.483,P0.01）. Conclusion The plasma BNP level is a senstive index reflecting the damage of cardiac function,it may be a useful biochemical parameter for evaluating the CHF.