代谢综合征患者氧化型低密度脂蛋白与颈动脉硬化的相关性

Correlation between oxidized low density lipoprotein and carotid atherosclerosis in patients with metabolic syndrome

目的探讨血清中氧化型低密度脂蛋白(oxidized low density lipoprotein,ox-LDL)水平与代谢综合征(metabolic syndrome,MS)患者危险因素和颈动脉内膜中层厚度(intima-media thickness,IMT)的关系及临床意义。方法入选86例MS患者和39例正常体检者,根据危险因素的数目分为低危MS组(n=42)和高危MS组(n=44),用彩色超声多普勒测定IMT,ELISA方法检测受试者血清中ox-LDL,进行单因素方差分析和Logistic回归分析。结果血清ox-LDL水平、IMT在正常对照组、低危MS组和高危MS组中依次增高,各组间差异有显著性(P<0.01)。以IMT>0.9mm为颈动脉硬化(carotid atherosclerosis,CA),Logistic回归分析结果示ox-LDL与CA独立相关,优势比为1.189(95%CI:1.078～1.312)。结论 ox-LDL是MS患者的CA的独立危险因素之一,血清ox-LDL可作为临床评价MS病情发展和CA的危险因子。

Objective To discuss the relationship and clinical significance among the level of serum oxidized low density lipoprotein（ox-LDL）,risk factors and carotid artery intima-media thickness（IMT） in the patients with metabolic syndrome（MS）.Methods MS patients（n=86） and normal controls（n=39） were chosen and MS patients were divided into the low risk factor group（n=42） and high risk factor group（n=44） according to the number of risk factors.IMT was determined by using color Doppler ultrasonography,the level of serum ox-LDL was detected by using ELISA and the all data were analyzed with one-way ANOVA and Logistic regression.Results The level of serum ox-LDL and IMT increased successively in the normal control group,low risk factor group and high risk factor group.The difference among all groups was significant（P0.01）.The results of Logistic regression analysis showed that if IMT0.9 mm was taken as the index of carotid atherosclerosis（CA）,the level of serum ox-LDL was correlated independently with CA and the odds ratio was 1.189（95% CI：1.078~1.312）.Conclusion The level of serum ox-LDL is one of independent risk factors of CA in MS patients,which can be used for review the development of MS and risk factors of CA in clinic.