摘要
目的探讨慢性肾功能不全(CRI)对非ST段抬高的急性冠脉综合征(NSTEACS)患者血浆N端脑钠肽前体(NT-proBNP)水平的影响。方法 154例患者分为NSTEACS合并CRI组(CRI组,99例)、单纯NSTEACS组(NSTEACS组,28例)及非冠心病对照组(CON组,27例)。采用电化学发光双抗体夹心免疫法测定患者血浆NT-proBNP水平,对NT-proBNP与估算肾小球滤过率(eGFR)及血肌酐(Cr)进行相关性分析。结果三组之间血浆NT-proBNP的自然对数(LnNT-proBNP)水平的差异有统计学意义(P<0.05),CRI组显著高于NSTEACS组及CON组,NSTEACS组显著高于CON组。LnNT-proBNP与eGFR呈负相关(r=-0.684,P<0.05),与Cr呈正相关(r=0.489,P<0.05)。校正年龄、血糖、血脂等影响因素后,LnNT-proBNP仍与eGFR呈负相关(r=-0.561,P<0.05),与Cr呈正相关(r=0.337,P<0.05)。结论除心功能不全外,肾功能不全亦影响NSTEACS患者血浆NT-proBNP水平。
Objective To investigate the influence of chronic renal insufficiency(CRI) on the level of plasma N-terminal pro brain natriuretic peptide(NT-proBNP) in the patients with non-ST-elevation acute coronary syndrome(NSTEACS).Methods All 154 patients were divided into the CRI group(NSTEACS complicating CRI,n=99),NSTEACS group(only NSTEACS,n=28) and control group(non-coronary heart disease,n=27).The level of plasma NT-proBNP were detected by applying electrochemiluminescence double-antibody sandwich immunoassay.The correlation between NT-proBNP and estimated glomerular filtration rate(eGFR) and creatinine(Cr) was analysed.ResultsThe difference of natural logarithm level of plasma NT-proBNP among three groups was significant statistically(P<0.05),and that was significantly higher in the CRI group than that in the NSTEACS group or control group,and that was significantly higher in the NSTEACS group than that in the control group.The natural logarithm level of plasma NT-proBNP was negatively related to eGFR(r=-0.684,P<0.05),and positively related to Cr(r=0.489,P<0.05).After correcting the factors including age,plasma glucose and blood fat,the natural logarithm level of plasma NT-proBNP was still negatively related to eGFR(r=-0.561,P<0.05),and positively related to Cr(r=0.337,P<0.05).Conclusion Besides cardiac insufficiency,renal insufficiency also influence the level of plasma NT-proBNP in the patients with NSTEACS.
出处
《中国循证心血管医学杂志》
2011年第2期138-140,共3页
Chinese Journal of Evidence-Based Cardiovascular Medicine
