他莫昔芬联合辅酶Q10治疗特发性少弱精子症临床疗效观察

Tamoxifen combined with coenzyme Q10 for idiopathic oligoasthenospermia

目的:探讨他莫昔芬(TMX)联合辅酶Q10(CoQ10)治疗对男性特发性少弱精子症患者精液参数的影响。方法:选取特发性少弱精子症患者183例,随机分为TMX+CoQ10(n=63)、TMX(n=61)及CoQ10治疗组(n=59)。治疗方法为,TMX:每次10 mg,2次/d,CoQ10:每次10 mg,3次/d,连续服用3个月为1个疗程。治疗前及治疗3、6个月后对外周血清性激素水平和精子浓度、活力及形态检测分析。结果:与治疗前相比,治疗6个月后,TMX+CoQ10及TMX治疗组血清FSH、LH、T水平明显升高(P<0.05),CoQ10治疗组较治疗前无明显变化(P>0.05);TMX+CoQ10及TMX治疗组精子浓度显著性提高(P<0.05),CoQ10组有所提高但无显著差异(P>0.05),TMX+CoQ10及CoQ10治疗组精子活力及正常形态精子百分率显著性提高(P<0.05),TMX治疗组有所提高但无显著差异(P>0.05)。结论:他莫昔芬联合辅酶Q10治疗特发性少弱精子症患者,可以显著改善精子浓度、活力及形态。

Objective： To investigate the effects of tamoxifen （TMX） combined with coenzyme Q10 （CoQ10） on idiopathic oli- goasthenospermia. Methods ： A total of 183 patients with idiopathic oligoasthenospermia were randomly divided into a TMX ＋ CoQIO group （ n = 63）, a TMX group （ n = 61 ） and a CoQ10 group （ n = 59）. At the end of 3 and 6 months of treatment, semen analyses and hormone tests were performed, and the results were compared with those obtained before the treatment. Results： Compared with the pre-treatment results, the levels of follicle-stimulating hormone （ FSH）, luteinizing hormone （LH） and testosterone （T） and sperm concentration were significantly elevated in the TMX ＋ CoQ10 and TMX groups （ P 〈 0.05 ）, but showed no significant difference in the CoQlO group （P 〉 0.05）; sperm motility and morphologically normal sperm were increased significantly in the TMX ＋ CoQ10 and CoQ10 groups（P 〈 0.05）, and slightly in the TMX group but with no statistically significant difference （P 〉 O. 05）. Conclusion： Tamoxifen combined with CoQ10 can significantly improve sperm concentration, motility and morphology in patients with idiopathic oligoasthenospermia.