曲张病变大隐静脉第一对瓣膜的病理改变

Pathological alterations of the first venous valve in great saphenous varicose vein

目的探讨曲张病变大隐静脉第一对瓣膜的病理改变。方法大隐静脉曲张(A)组24例,正常对照(C)组3例,分别采用HE、Sirius Red染色及CD31、-αSMA免疫组织化学法检测大隐静脉第一对静脉瓣在曲张病变中的病理改变。结果与C组比较,A组静脉瓣膜延伸变长、扭曲变形,伴胶原纤维增生,瓣膜两侧内皮细胞表达CD31不一致(P<0.05),并异常高表达-αSMA(P<0.05)。结论曲张大隐静脉中瓣膜的形态、结构、内皮均发生了明显病理改变,提示静脉瓣膜的这些改变在下肢静脉曲张的发病机制中起重要作用。

Objective To investigate the pathological alterations of the first valve in great saphenous varicose vein.Methods The pathological chnges in the first valve of 24 great saphenous varicose veins（group A） and 3 normal great saphenous veins were observed with HE and Sirius red staining.CD31 and α-SMA were detected using immunohistochemistry as well.Results Compared to group C,valves of group A appeared to be twisted and lengthened with hyperplasia of collagen fiberand,different expressions of CD31 in endothelium cells on two sides and highly expressed α-SMA（P0.05）.Conclusion Significant alterations in morphology,structure,endothelium in the first valve of great saphenous varicose vein are seen,which may play an important role in the pathogenesis of primary varicose veins.