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4-甲基-5-乙烯基尼古丁腈的合成

Synthesis of 4-methyl-5-vinylnicotinonitrile
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摘要 以2-乙酰丁酸内酯和氰乙酰胺为原料,经缩合、氯代、催化氢化以及消除4步反应,合成了标题化合物,总收率59.9%。产物结构经核磁共振氢谱和质谱确认。 4-Methyl-5-vinylnicotinonitrile was synthesized from 2-acetylbutyrolactone and cyanoacetamide in four steps with an overall yield of 59.9%.The structure of the target compound was confirmed by 1HNMR and MS analyses.
作者 冯启国 张杨 任凤霞 杨郁 刘津 赵毅民
机构地区 军事医学科学院毒物药物研究所
出处 《化学试剂》 CAS CSCD 北大核心 2011年第7期655-656,672,共3页 Chemical Reagents
基金 综合性新药研究开发技术大平台资助项目(2009ZX09301-002)
关键词 氰乙酰胺 4-甲基-5-乙烯基尼古丁腈 合成 cyanoacetamide 4-methyl-5-vinylnicotinonitrile synthesis
分类号 O626.32 [理学—有机化学]
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化学试剂
2011年 第7期

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