摘要
机体的免疫系统通过多种机制来调节免疫应答，有效的抵御病原体入侵、维持内环境稳定。淋巴细胞活化基因-3分子（LAG-3）是免疫球蛋白超家族的一员，与CD4密切相关，选择性地表达在活化的T淋巴细胞、自然杀伤（NK）细胞和树突状细胞（DC）中，通过与其配基MHCⅡ类分子结合发挥。免疫调节的功能，维持内环境稳定。与肿瘤、结核等多种疾病相关，它的发现为相关疾病的免疫治疗提供了新的靶点。
The immune system regulate the immue response through many mechanisms, effectively against invading pathogens, maintain homeostasis, lymphocyte activation gene-3 （ LAG-3 ; CD223 ） , a member of the immunoglobulin superfamily （IgSF） closely related to CD4, is selectively expressed in activated T lymphocyte cells , nature killer cells and dendritic cells. LAG-3 binds to MHC class Ⅱ molecules and plays a regulatory role in both immune response and homeostasis of internal milieu. Moreover, LAG-3 is related to the development of tumour and tuberculosis, and provide novel immue therapeutic targets for related diseases.
出处
《国际免疫学杂志》
CAS
北大核心
2011年第4期265-269,共5页
International Journal of Immunology
关键词
LAG-3
T细胞
树突状细胞
肿瘤
结核
Lymphocyte activation gene-3
T cell
Dendritic cell
Turnout
Tuberculosis
