Survivin在口腔扁平苔藓癌变过程中的表达

The expression of Survivin in oral lichen planus and oral squamous cell carcinoma

目的探讨凋亡抑制因子Survivin在口腔扁平苔藓(OLP)、口腔鳞状细胞癌(OSCC)中的表达及意义。方法采用免疫组织化学SP法检测40例糜烂型OLP组织、40例OSCC组织以及26例正常口腔黏膜组织中Survivin蛋白的表达,并分析其意义。结果 Survivin蛋白在正常口腔黏膜、糜烂型OLP及OSCC中的表达率分别为4%、30%、55%,三组相比,差异均有统计学意义(P<0.05)。OSCC中Survivin表达与组织分化程度无显著相关关系。结论 Survivin在OLP和OSCC中高表达,在OLP向OSCC转变的发生发展中可能起着重要作用。

Objective To study the expression and clinical significance of survivin,a novel member of inhibitorof apoptosis protein family,in oral lichen planus（OLP） and oral squamous cell carcinoma（OSCC）.MethodsStreptavidin-percocidase immunohistochemical technique was used to detect the expression of survivin protein in40 cases of OSCC,40 cases of OLP tissues and 26 cases of normal oral mucosa,and its dependability was analyzed.Results The positive expression of survivin was detected in 22 cases of OSCC tissues（55%）,in 12 casesof OLP tissues（30%）,and in 1 case of normal oral mucosa（4%）.The positive rates of survivin expression weresignificantly higher in OSCC and OLP than the normal oral mucosa（P0.05）.Conclusion Survivin gene maybeone of the important factors in the development and progress of OSCC and OLP.Survivin may has relationship with the process of OLP transform to OSCC.