摘要
目的:探讨环氧合酶-2(Cox-2)在宫颈上皮内瘤变及宫颈癌中的表达,及其与宫颈病变发生发展的关系。方法:采用免疫组织化学S-ABC法,检测了16例原发性宫颈癌,39例宫颈上皮内瘤变,8例正常宫颈组织中Cox-2的表达。结果:Cox-2在宫颈上皮内瘤变组及宫颈癌组中的表达明显高于正常宫颈组织(P<0.05),宫颈上皮内瘤变组与宫颈癌组比较,差异有统计学意义(P<0.05);Cox-2在中度宫颈上皮内瘤变组及重度宫颈上皮内瘤变组中的表达明显高于轻度宫颈上皮内瘤变组(P<0.05),中度宫颈上皮内瘤变组与重度宫颈上皮内瘤变组比较,差异无统计学意义(P>0.05)。结论:Cox-2表达上调与宫颈癌的形成有关,在宫颈上皮内瘤变的发生发展中起重要作用。
Objective：To detect the expression of cyclooxygenase-2（cox-2） in cervical intraepithelial neoplasia（CIN） and primany cervical cancer and to evaluate whether it could provide clinical significant informations.Methods：The expression of cox-2 was studied by immunohistochemical Strep-Aviodin-Biotin-enzyme-Complex method（S-ABC） in 16 cases of primany cervical cancer,39 cases of CIN and 8 cases of normal cervical tissue.Results：The positive rate in the CIN and cervical carcinoma was higher than normal cervical tissues（P0.05）.The level of Cox-2 was higher in cancer samples compared respectively with cervical intraepithelial neoplasias（P0.05）.The level of Cox-2 was higher in both CINⅡ and CINⅢ compared respectively with CINⅠ（P0.05）.There was no significant difference of Cox-2 between CINⅡand CINⅢ（P0.05）.Conclusion：The expression of Cox-2 is related to the generation of cervical cancer,and it plays an importment role in the generation and development of CIN.
出处
《中国医药导报》
CAS
2011年第20期24-25,共2页
China Medical Herald
