子痫前期孕妇血脂水平变化及临床意义

Changes and clinical significance of blood lipid levels in pregnant women with preeclamptic

目的:探讨子痫前期孕妇血脂水平的变化及临床意义。方法:随机选取子痫前期孕妇60例为子痫前期组,正常孕妇60例为正常妊娠组。比较两组血脂水平。结果:子痫前期组TC、TG、LDL-C、ApoB、AI明显高于正常妊娠组(t=3.91、4.32、4.87、4.22、4.31,P<0.05);ApoAI低于正常妊娠组(t=3.96,P<0.05);HDL-C低于正常妊娠组,但无显著性差异(t=2.52,P>0.05);重度TG、LDL-C、ApoB、AI明显高于轻度(t=5.11、4.13、3.94、4.43,P<0.05),而TC、HDL-C、ApoAI与轻度无显著差异(t=1.21、2.12、1.87,P>0.05)。结论:子痫前期孕妇存在着明显血脂代谢异常,并且随病情加重而更加紊乱,孕期应严密监测血脂水平,作为预测和诊断子痫前期发病与疾病程度的依据。

Objective：To investigate the changes and clinical significance of blood lipid levels in pregnant women with preeclamptic.Methods：60 cases pregnant women with preeclampsia were randomly selected as preeclampsia group,60 cases normal pregnant women as normal pregnancy group.Blood lipid level of two groups were deceted.Results：TC,TG,LDL-C,ApoB,AI in preeclampsia group were significantly higher than those in the normal pregnancy group（t=3.91,4.32,4.87,4.22,4.31,P0.05）;ApoAI was lower than that in the normal pregnancy group（t=3.96,P0.05）;HDL-C was lower than the normal pregnancy group,but there was no significant difference（t=2.52,P0.05）;Severe preeclamptic TG,LDL-C,ApoB,AI were significantly higher than those in the mild preeclamptic（t=5.11,4.13,3.94,4.43,P0.05）,TC,HDL-C,ApoAI have no significant difference with mild preeclamptic（t=1.21,2.12,1.87,P0.05）.Conclusion：Pregnant women with preeclamptic exists obviously abnormal lipid metabolism and more disordered with illness exacerbations during pregnancy,they should be monitored closely during pregnancy,as prediction and diagnosis of preeclampsia with disease degree of basis.