动脉瘤蛛网膜下腔出血患者血清垂体激素含量变化的研究

Contents changes of the serum concentration of pituitary hormone in patients with aneurysmal subarachnoid hemorrhage

目的:探讨动脉瘤蛛网膜下腔出血(SAH)患者血清促甲状腺激素(TSH)、促肾上腺皮质激素(ACTH)、黄体生成素(LH)、卵泡刺激素(FSH)含量的变化及临床意义。方法:选取50例动脉瘤性SAH患者。在其发病后的1～3、7～9、14～17 d对血清TSH、ACTH、LH、FSH进行动态观察,同时用TCD检测大脑中动脉血流速度(VMCA)。结果:动脉瘤性SAH患者血清TSH、ACTH、LH、FSH发病后1～3、7～9 d各均值明显高于对照组(P<0.05);脑血管痉挛组与非脑血管痉挛组比较有显著性差异(P<0.05)。结论:动脉瘤性SAH患者血清TSH、ACTH、LH、FSH含量与病情严重程度、脑血管痉挛程度相关,可作为判断预后的标准。

Objective：To explore contents changes of pituitary hormone in serum TSH,ACTH,LH and FSH levels in patients with aneurysmal subarachnoid hemorrhage and its clinical significance.Methods：Selected 50 cases of patients with aneurysmal SAH.In its incidence after 1-3 d,7-9 d,14-17 d serum TSH,ACTH,LH,FSH dynamic observation,meanwhile with TCD detection cerebral artery flow speed（VMCA）.Results：Aneurysmal SAH patients serum TSH,ACTH,LH,FSH incidence after 1-3 d,7-9 d obviously higher than the average in control group（P0.05）.Cerebral vasospasm group and the cerebral non-vasospasm group with significant difference（P0.05）.Conclusion：Aneurysmal SAH patient serum TSH,ACTH,LH,FSH contents are related with severe,cerebral vasospasm degree,can be used as standard of prognosis.