摘要
目的:观察水翁花的镇痛和抗内毒素作用,为镇痛和抗内毒素药物的临床开发与应用提供可靠的实验依据。方法:采用醋酸扭体法观察水翁花的镇痛作用,采用内毒素致小鼠休克死亡法观察水翁花的抗内毒素作用。结果:小鼠连续7天灌胃给予水翁花16、8和4g/kg,均能明显减少醋酸所致的扭体反应次数,能明显提高内毒素血症小鼠生存率(P<0.05)。结论:水翁花对外周性疼痛有镇痛作用,对内毒素引起的多器官损伤有保护作用。
Objective：To study the analgesic and anti-endotoxic effects of Cleistocalyx operculatus,and to probide experimental evidences for the clinical development and application.Methods：The analgesic effect was studied with the writhing test by induced acetic acid and the anti-endotoxic effect was observed by the desth mice induced by endotoxin.Results：The extract of Cleistocalyx operculatus at diferent doses（16,8,4 g·kg-1）could reduced the stretching times significantly,improve the survival rate of endotoxemia mice.Conclusion：The extract of C.operculatus has obvious analgesic effects and protective effect on endotoxin induced multiple organ injury.
出处
《中华中医药学刊》
CAS
2011年第7期1569-1570,共2页
Chinese Archives of Traditional Chinese Medicine
基金
广东省中医药管理局资助项目(2009081)
中山市科技基金资助项目(20091A044)
关键词
水翁花
镇痛
内毒素
Cleistocalyx operculatus
analgesia
endotoxin
