大鼠高尿酸血症模型的建立

Establishment of Hyperuricemia Model in SPF SD Rats

目的建立大鼠高尿酸血症动物模型。方法采用腺嘌呤、腺嘌呤加酵母、腺嘌呤加乙胺丁醇和氧嗪酸钾盐不同剂量口服灌胃,测定实验前后大鼠血清尿酸、尿素氮、肌酐,并进行组织学病理切片观察。结果氧嗪酸钾尿酸升高平稳,并且对肾损伤不严重。结论用氧嗪酸钾建立大鼠高尿酸血症模型较合适。

Objective To establish a hyperuricemia model in SD rats.Methods Different doses of adenine,adenine and yeast,adenine and ethambutol and oxonic acid were administrated to the SD rats by oral gavage.Concentrations of serum uric acid,urine nitrogen and creatinine were measured,before and after treatments.Pathological examination of renal tissue were carried out.Results The serum uric acid of the oxonic acid treated groups was increased smoothly,steady and there was no significant renal damage at a long time.Conclusion The oxonic acid is suitable for preparation of hyperuricemia model in SD rats.