斑马鱼甘露糖结合蛋白基因的分离及生物信息学分析
摘要
甘露糖结合蛋白是动物免疫系统中的重要组分,是参与动物补体激活途径的重要分子。本研究分离鉴定了一个斑马鱼甘露糖结合蛋白基因。通过生物信息学分析和分子建模发现其与哺乳动物和原鸡的甘露糖结合蛋白有高度序列和结构的相似性。该基因的鉴定为鱼类补体系统的研究提供了有意义的信息。
出处
《科技信息》
2011年第18期I0116-I0117,共2页
Science & Technology Information
参考文献9
-
1刘梅,赵忠利,仲跻峰,王长法.甘露糖结合凝集素基因的研究进展[J].中国畜牧兽医,2009,36(6):45-49. 被引量:4
-
2Fujita, T., M. Matsushita, and Y. Endo.The lectin-complement pathway: its role in innate immunity and evolution. Immunol. Rev,2004. 198: 185-202.
-
3Takahashi M, Iwaki D, Matsushita A, Nakata M, Matsushita M, Endo Y, Fujita T.Cloning and Characterization of Mannose-Binding Lectin from Lamprey (Agnathans). J. Immunol, 2006.176;4861-4868.
-
4Ezekowitz, R.A.Role of the mannose-binding lectin in innate immunity. J. Infect. Dis, 2003.187: S335-S339.
-
5Holmskov, U., S. Thiel, and J. C. Jensenius.Collections and ficolins: humoral lectins of the innate immune defense. Annu. Rev. Immunol, 2003.21: 547-578.
-
6Weis, W. I., K. Drickamer, and W. A. Hendrickson.Structure of a C-type mannose-binding protein complexed with an oligosaccharide.Nature, 1992.360: 127-.134.
-
7Holmskov, U., R. Malhotra, R. B. Sim, andJ. C. Jensenius. Collectins: coUagenous C-type lectins of the innate immune defense system. Immunol. Today, 1994.15: 67-74.
-
8Fujita, T.Evolution of the lectin-complement pathway and its role in innate immunity. Nat. tKev. Imrnunol,2002.2: 346-353.
-
9Drickamer, K.Engineering galactose-binding activity into a C-type mannose-binding protein. Nature, 1992.360: 183-186.
二级参考文献29
-
1余新沛,吕成伟,葛争鸣,李江川,马丽,陈政良.中国佤族人群MBL基因SNP及其单倍型与基因型的研究[J].中华微生物学和免疫学杂志,2005,25(11):917-918. 被引量:4
-
2梁剑峰,肖亚彬.鸡甘露糖结合凝集素的研究进展[J].中国禽业导刊,2005,22(20):38-38. 被引量:2
-
3Mccullough K C,Schaffner R, Ntale V, et al. Phenotype of porcine monocytic cells: modulation of surface molecule expression upon monocyte differentiation into macrophages. Vet Immunol Immunopathol, 1997, (3-4) : 265 - 275.
-
4Moller-Kristensen M, et al. Deficiency of mannose-binding lectin greatly increases susceptibility to postburn infection with Pseudomonas aeruginosa. J Immunol, 2006,176(3) : 1769- 1775.
-
5Phatsara C,Jennen D J, Ponsuksili S, et al. Molecular genetic a nalysis of porcine mannose-binding lectin genes, MBL1, MBL2 and their association with complement activity. Int J Immuno genet,2007,34(1) :55-63.
-
6Podolsky M J, Lasker A, Flaminio M J, et al. Characterization of an equine mannose-binding leetin and its roles in disease. Biochem Biophys Res Commun, 2006,343 (3) : 928- 936.
-
7Saevarsdottir S, Vikingsdottir T, Vikingsson A, et al. Low mannose binding lectin predicts poor prognosis in patients with early rheumatoid arthritis-- A prospective study. J Rheumatol, 2001, 28(4) : 728- 734.
-
8Sastry K, Herman G A,Day L, et al. The human mannose-binding protein gene-Exon structure reveals its evolutionary relationship to a human pulmonary surfactant gene and localization to chromosome 10. J Exp Med,1989,170:1175-1189.
-
9Seyfarth J, Garred P, Madsen H O. The ' involution' of mannose-binding lectin. Hum Mol Genet, 2005,14 (19) :2859 - 2869.
-
10Sorensen G L, Petersen I, Thiel S, et al. Genetic influences on mannan-binding lectin (MBL) and mannan-binding lectin associated serine protease-2 (MASP-2) activity. Genet Epidemiol, 2007,31(1) :31-41.
共引文献3
-
1金遵,赵宗胜,袁聪,于要升,曹少奇,雷小萍.不同MBL基因型绵羊感染绵羊肺炎支原体后的免疫相关因子表达规律分析[J].畜牧与兽医,2015,47(11):34-39. 被引量:2
-
2金遵,赵宗胜,袁聪,于要升,曹少奇,雷小萍.绵羊甘露糖结合凝集素基因启动子区甲基化与绵羊支原体肺炎相关性研究[J].中国预防兽医学报,2016,38(5):356-360. 被引量:1
-
3王莉,张杰,赵贤亮,狄桂兰,孔祥会.鱼类C-型凝集素结构特征及其免疫功能[J].水产科学,2019,38(2):282-288. 被引量:4
-
1彭良平,郭明秋.甘露糖结合蛋白研究[J].科学(中文版),1996(6):53-56. 被引量:1
-
2施红,王福生,金磊,雷周云,张冰,刘明旭.中国人甘露糖结合蛋白基因第1外显子核苷酸序列的测定[J].传染病信息,2001,14(1):20-23.
-
3陆晨,侯丽娜,岳华.甘露糖结合蛋白研究进展[J].医学综述,2008,14(6):928-930. 被引量:2
-
4刘武,阮颖,刘春林.植物防御信号分子β-罗勒烯的研究进展[J].植物生理学报,2012,48(2):103-110. 被引量:16
-
5彭良平.甘露糖结合蛋白的结构与功能[J].国外医学(分子生物学分册),1997,19(1):22-26. 被引量:1
-
6Clifford A Adams,郑君杰(编译),齐广海(审校),李海涛(审校).饲料对动物免疫系统的影响[J].饲料与畜牧(新饲料),2009(2):20-24.
-
7童福易,马欣,朱传武.MBP基因突变与感染性疾病的关系的研究进展[J].国外医学(分子生物学分册),2003,25(3):140-143. 被引量:4
-
8施红,王福生,金磊,刘明旭,洪卫国,杜清友,雷周云,侯静,施明,邢利和.中国五个民族的甘露糖结合蛋白基因多态性特点及意义[J].中华医学遗传学杂志,2001,18(3):202-205. 被引量:21
-
9刘祖碧,朱乾坤,李娟娟,宋涛,周嘉裕,王万军,廖海.唐松草小檗碱桥酶的序列分析与结构建模研究[J].生物技术,2013,23(6):42-46.
-
10梁剑峰,肖亚彬.鸡甘露糖结合凝集素的研究进展[J].中国禽业导刊,2005,22(20):38-38. 被引量:2